The Diagnostic Significance of C3d Antigen in Kidney and Skin Histopathology - The Current State-Of-The-Art and Practical Examples
Jazyk angličtina Země Česko Médium print
Typ dokumentu přehledy, časopisecké články
PubMed
37888966
PubMed Central
PMC10669952
DOI
10.33549/physiolres.935175
PII: 935175
Knihovny.cz E-zdroje
- MeSH
- kůže MeSH
- ledviny * patologie MeSH
- monoklonální protilátky MeSH
- transplantace ledvin * MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- monoklonální protilátky MeSH
The aim of this narrative review is to summarize recent knowledge about the diagnostic significance of immunobiological detection of C3d with a focus on renal and skin tissue biopsies. We completed the present narrative review with our own experiences with preparation and practical use of monoclonal C3d antibodies at a small national level.
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Toapanta FR, Ross TM. Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity. Immunol Res. 2006;36:197–210. doi: 10.1385/IR:36:1:197. PubMed DOI
Kinoshita T. Biology of complement: the overture. Immunol Today. 1991;12:291–295. doi: 10.1016/0167-5699(91)90001-A. PubMed DOI
Thurman JM, Kulik L, Orth H, Wong M, Renner B, Sargsyan SA, Mitchell LM, et al. Detection of complement activation using monoclonal antibodies against C3d. J Clin Invest. 2013;123:2218–2230. doi: 10.1172/JCI65861. PubMed DOI PMC
Gierej B, Górnicka B, Wasiutyński A. Role of C3d and C4d complement fragments in the diagnostics of acute allograft rejection after transplantations. Ann Transplant. 2009;14:61–70. PubMed
Snijders MLH, van de Wall-Neecke BJ, Hesselink DA, Becker JU, Clahsen-van Groningen MC. Utility of immunohistochemistry with C3d in C3 glomerulopathy. Mod Pathol. 2020;33:431–439. doi: 10.1038/s41379-019-0348-z. PubMed DOI
Lamb KE, Lodhi S, Meier-Kriesche HU. Long-term renal allograft survival in the United States: a critical reappraisal. Am J Transplant. 2011;11:450–462. doi: 10.1111/j.1600-6143.2010.03283.x. PubMed DOI
Pratt JR, Basheer SA, Sacks SH. Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med. 2002;8:582–587. doi: 10.1038/nm0602-582. PubMed DOI
Corrêa RR, Machado JR, da Silva MV, Helmo FR, Guimarães CS, Rocha LP, Faleiros AC, dos Reis MA. The importance of C4d in biopsies of kidney transplant recipients. Clin Dev Immunol. 2013;2013:678180. doi: 10.1155/2013/678180. PubMed DOI PMC
Nankivell BJ, Alexander SI. Rejection of the kidney allograft. N Engl J Med. 2010;363:1451–1462. doi: 10.1056/NEJMra0902927. PubMed DOI
Eggertsen G, Nyberg G, Nilsson B, Nilsson U, Svalander CT. Complement deposition in renal allografts with early malfunction. APMIS. 2001;109:825–834. doi: 10.1034/j.1600-0463.2001.091204.x. PubMed DOI
Cornell LD. Histopathologic Features of Antibody Mediated Rejection: The Banff Classification and Beyond. Front Immunol. 2021;12:718122. doi: 10.3389/fimmu.2021.718122. PubMed DOI PMC
Ozaki M, Kang Y, Tan YS, Pavlov VI, Liu B, Boyle DC, Kushak RI, et al. Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injury. Kidney Int. 2016;90:774–782. doi: 10.1016/j.kint.2016.05.011. PubMed DOI PMC
Okada M, Yoshioka K, Takemura T, Akano N, Aya N, Murakami K, Maki S. Immunohistochemical localization of C3d fragment of complement and S-protein (vitronectin) in normal and diseased human kidneys: association with the C5b-9 complex and vitronectin receptor. Virchows Arch A Pathol Anat Histopathol. 1993;422:367–373. doi: 10.1007/BF01605455. PubMed DOI
Leivo I, Engvall E. C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast. J Cell Biol. 1986;103:1091–1100. doi: 10.1083/jcb.103.3.1091. PubMed DOI PMC
Yatim KM, Azzi JR. Novel Biomarkers in Kidney Transplantation. Semin Nephrol. 2022;42:2–13. doi: 10.1016/j.semnephrol.2022.01.007. PubMed DOI
Sicard A, Ducreux S, Rabeyrin M, Couzi L, McGregor B, Badet L, Scoazec JY, et al. Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss. J Am Soc Nephrol. 2015;26:457–467. doi: 10.1681/ASN.2013101144. PubMed DOI PMC
Sapir-Pichhadze R, Curran SP, John R, Tricco AC, Uleryk E, Laupacis A, Tinckam K, Sis B, Beyene J, Logan AG, Kim SJ. A systematic review of the role of C4d in the diagnosis of acute antibody-mediated rejection. Kidney Int. 2015;87:182–194. doi: 10.1038/ki.2014.166. PubMed DOI
Kuypers DR, Lerut E, Evenepoel P, Maes B, Vanrenterghem Y, Van Damme B. C3D deposition in peritubular capillaries indicates a variant of acute renal allograft rejection characterized by a worse clinical outcome. Transplantation. 2003;76:102–108. doi: 10.1097/01.TP.0000069040.16457.06. PubMed DOI
Pelletier RP, Balazs I, Adams P, Rajab A, DiPaola NR, Henry ML. Clinical utility of C3d binding donor-specific anti-human leukocyte antigen antibody detection by single antigen beads after kidney transplantation-a retrospective study. Transpl Int. 2018;31:424–435. doi: 10.1111/tri.13106. PubMed DOI
Lv R, Zhang W, Han F, Liu G, Xie W, Chen J. Capillary deposition of complement C4d and C3d in Chinese renal allograft biopsies. Dis Markers. 2015;2015:397613. doi: 10.1155/2015/397613. PubMed DOI PMC
Ma R, Cui Z, Hu SY, Jia XY, Yang R, Zheng X, Ao J, et al. The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. PLoS One. 2014;9:e91250. doi: 10.1371/journal.pone.0091250. PubMed DOI PMC
Villacorta J, Diaz-Crespo F, Acevedo M, Guerrero C, Campos-Martin Y, García-Díaz E, Mollejo M, Fernandez-Juarez G. Glomerular C3d as a novel prognostic marker for renal vasculitis. Hum Pathol. 2016;56:31–39. doi: 10.1016/j.humpath.2016.05.015. PubMed DOI
Zhang R, Lin J, Qu L, Zheng F, Zheng Z. C3d deposition in the media of renal arterioles is a useful marker for arteriolosclerosis in IgA nephropathy. Ann Diagn Pathol. 2014;18:104–108. doi: 10.1016/j.anndiagpath.2014.01.001. PubMed DOI
Boudhabhay I, Poillerat V, Grunenwald A, Torset C, Leon J, Daugan MV, Lucibello F, et al. Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis. Kidney Int. 2021;99:581–597. doi: 10.1016/j.kint.2020.09.033. PubMed DOI
Pfister F, Vonbrunn E, Ries T, Jäck HM, Überla K, Lochnit G, Sheriff A, et al. Complement Activation in Kidneys of Patients With COVID-19. Front Immunol. 2021;11:594849. doi: 10.3389/fimmu.2020.594849. PubMed DOI PMC
Magro CM, Dyrsen ME. The use of C3d and C4d immunohistochemistry on formalin-fixed tissue as a diagnostic adjunct in the assessment of inflammatory skin disease. J Am Acad Dermatol. 2008;59:822–833. doi: 10.1016/j.jaad.2008.06.022. PubMed DOI
Rosi-Schumacher M, Baker J, Waris J, Seiffert-Sinha K, Sinha AA. Worldwide epidemiologic factors in pemphigus vulgaris and bullous pemphigoid. Front Immunol. 2023;14:1159351. doi: 10.3389/fimmu.2023.1159351. PubMed DOI PMC
Wang LL, Moshiri AS, Novoa R, Simpson CL, Takeshita J, Payne AS, Chu EY. Comparison of C3d immunohistochemical staining to enzyme-linked immunosorbent assay and immunofluorescence for diagnosis of bullous pemphigoid. J Am Acad Dermatol. 2020;83:172–178. doi: 10.1016/j.jaad.2020.02.020. PubMed DOI PMC
Oh H, Kim CH, Lee YJ. Bullous pemphigoid diagnosis: the role of routine formalin-fixed paraffin-embedded skin tissue immunochemistry. Sci Rep. 2022;12:10519. doi: 10.1038/s41598-022-14950-z. PubMed DOI PMC
Pfaltz K, Mertz K, Rose C, Scheidegger P, Pfaltz M, Kempf W. C3d immunohistochemistry on formalin-fixed tissue is a valuable tool in the diagnosis of bullous pemphigoid of the skin. J Cutan Pathol. 2010;37:654–658. doi: 10.1111/j.1600-0560.2009.01450.x. PubMed DOI
Guo L, Jacobson R, Vaughan H, Connolly MK, Seiger K, Haemel AK, North J. C3d immunohistochemistry in the diagnosis of bullous pemphigoid: A comparative diagnostic test accuracy and cost analysis study. J Am Acad Dermatol. 2023;89:413–415. doi: 10.1016/j.jaad.2023.04.016. PubMed DOI
Al-Shenawy HA. Can immunohistochemistry replace immunofluorescence in diagnosis of skin bullous diseases? APMIS. 2017;125:114–121. doi: 10.1111/apm.12643. PubMed DOI
Ashrafzadeh S, Fedeles F. What the rheumatologist needs to know about skin biopsy. Best Pract Res Clin Rheumatol. 2023:101838. doi: 10.1016/j.berh.2023.101838. PubMed DOI
Niebel D, de Vos L, Fetter T, Brägelmann C, Wenzel J. Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions. Am J Clin Dermatol. 2023;24:521–540. doi: 10.1007/s40257-023-00774-8. PubMed DOI PMC
Deng M, Zhou X, Zhang J, Li Y. Immunohistochemical analysis for C3d, C4d, IgG, IgG4, and CD123 in diagnosis of autoimmune skin diseases (Article in Chinese) Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019;44:878–884. PubMed
Deng M, Wu R, Zhou X, Su Y, Li Y. Analyses of the clinical and immunological characteristics of patients with lupus erythematosus. Indian J Dermatol. 2022;67:205. doi: 10.4103/ijd.ijd_942_20. PubMed DOI PMC
Tiller G, Lammerts RGM, Karijosemito JJ, Alkaff FF, Diepstra A, Pol RA, Meter-Arkema AH, et al. Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney. Front Immunol. 2022;13:845301. doi: 10.3389/fimmu.2022.845301. PubMed DOI PMC
Thurman JM, Kulik L, Orth H, Wong M, Renner B, Sargsyan SA, Mitchell LM, et al. Detection of complement activation using monoclonal antibodies against C3d. J Clin Invest. 2013;123:2218–2230. doi: 10.1172/JCI65861. PubMed DOI PMC
Bordron A, Bagacean C, Tempescul A, Berthou C, Bettacchioli E, Hillion S, Renaudineau Y. Complement System: a Neglected Pathway in Immunotherapy. Clin Rev Allergy Immunol. 2020;58:155–171. doi: 10.1007/s12016-019-08741-0. PubMed DOI