Since the beginning of the COVID-19 pandemic, there has been an overall improvement in patient mortality. However, haematological malignancy patients continue to experience significant impacts from COVID-19, including high rates of hospitalization, intensive care unit (ICU) admissions, and mortality. In comparison to other haematological malignancy patients, individuals with chronic myeloid leukemia (CML) generally have better prognosis. This study, conducted using a large haematological malignancy patient database (EPICOVIDEHA), demonstrated that the majority of CML patients experienced mild infections. The decline in severe and critical infections over the years can largely be attributed to the widespread administration of vaccinations and the positive response they elicited. Notably, the mortality rate among CML patients was low and exhibited a downward trend in subsequent years. Importantly, our analysis provided confirmation of the effectiveness of vaccinations in CML patients.

1 Department of Medicine University Medical Center Hamburg Eppendorf Hamburg Germany

3 Department of Medicine University Medical Center Hamburg Eppendorf Hamburg Germany

Amsterdam UMC Location VUmc Amsterdam Netherlands

AZ KLINA Brasschaat Belgium

Azienda Ospedaliera Nazionale SS Antonio e Biagio e Cesare Arrigo Alessandria Italy

Azienda Ospedaliera San Gerardo Monza Monza Italy

Center for Molecular Medicine Cologne University of Cologne Faculty of Medicine and University Hospital Cologne Cologne Germany

Centre Hospitalier de Versailles Le Chesnay France

Clinic for Orthopedic Surgery and Traumatology University Clinical Center of Serbia Belgrade Serbia

Clinical Trials Centre Cologne University of Cologne University Hospital Cologne Cologne Germany

Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases University of Cologne University Hospital Cologne Institute of Translational Research Cologne Germany

Communicable Disease Center Hamad Medical Corporation Doha Qatar

Complejo Hospitalario de Navarra Iruña Pamplona Spain

COVID 19 Hospital Batajnica Belgrade Serbia

Department 1 of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf University of Cologne University Hospital Cologne Cologne Germany

Department of Clinical and Biological Sciences University of Turin Turin Italy

Department of Hematology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark

Department of Hematology Research Unit Hospital Universitario de Burgos Burgos Spain

Department of Hematology University Hospital Virgen Macarena University Hospital Virgen del Rocío Instituto de Biomedicina de Sevilla Seville Spain

Department of Hematology UZ Leuven Leuven Belgium

Department of Infectious Diseases Karolinska University Hospital Stockholm Sweden

Department of Internal Medicine ADRZ Goes Netherlands

Department of Internal Medicine Hematology and Oncology Masaryk University Hospital Brno Brno Czech Republic

Department of Medicine and Surgery University of Insubria and ASST Sette Laghi Ospedale di Circolo of Varese Varese Italy

Department of Medicine Section of Hematology University of Verona Verona Italy

Department of Microbiology Immunology and Transplantation KULeuven Leuven Belgium

Department of Oncology Hematology and Bone Marrow Transplantation with Section of Pneumology University Medical Center Hamburg Eppendorf Hamburg Germany

Division of Hematology and Medical Oncology Department of Internal Medicine Universitas Indonesia Cipto Mangunkusumo Hospital Jakarta Indonesia

Division of Hematology Dokuz Eylul University Izmir Turkey

Ematologia con Trapianto Ospedale Dimiccoli Barletta Barletta Italy

Federal University of Rio de Janeiro Rio de Janeiro Brazil

Fundacion Jimenez Diaz University Hospital Health Research Institute IIS FJD Madrid Spain

German Centre for Infection Research Partner Site Bonn Cologne Cologne Germany

Hematology and Stem Cell Transplant Unit IRCCS Regina Elena National Cancer Institute Rome Italy

Hematology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy

Hematology Unit Università Cattolica del Sacro Cuore Rome Italy

Hospital Escuela de Agudos Dr Ramón Madariaga Posadas Argentina

Hospital Nuestra Señora de Sonsoles Ávila Spain

Hospital Universitario 12 de Octubre Madrid Spain

Hospital University of Parma Hematology and Bone Marrow Unit Parma Italy

Institute of Hematology and Blood Transfusion Prague Czech Republic

IRCCS Ospedale San Raffaele Milan Italy

King's College Hospital London UK

Memorial Cancer Hospital and Research Centre Lahore Pakistan

NIHR Oxford Biomedical Research Centre Churchill Hospital Oxford UK

Oncology Center Mansoura University Mansoura Egypt

Ospedale San Bortolo Vicenza Italy

Portuguese Institute of Oncology Lisbon Portugal

San Luigi Gonzaga Hospital Orbassano Orbassano Italy

Shaukat Khanum Memorial Cancer Hospital and Research Centre Lahore Pakistan

Sultan Qaboos University Hospital Muscat Oman

Università Milano Bicocca Milan Italy

Université Paris Saclay UVSQ Inserm Équipe Exposome et Hérédité CESP Villejuif France

University Hospital Hradec Králové Hradec Králové Czech Republic

University Hospital Olomouc Olomouc Czech Republic

University Medical Center Groningen Groningen Netherlands

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