Benign female genital tract smooth muscle tumors with adipocytic differentiation: A morphologic, immunohistochemical and MDM2 fluorescence in situ hybridization study of 44 conventional lipoleiomyomas and lipoleiomyoma variants
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
37972871
DOI
10.1016/j.humpath.2023.10.006
PII: S0046-8177(23)00220-4
Knihovny.cz E-zdroje
- Klíčová slova
- Leiomyomas, Leiomyomas with adipocytic differentiation, Lipoleiomyomas, Smooth muscle tumors,
- MeSH
- dospělí MeSH
- hybridizace in situ fluorescenční MeSH
- leiomyom * patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipom * genetika patologie MeSH
- nádor z hladké svalové tkáně * MeSH
- nádory dělohy * patologie MeSH
- protoonkogenní proteiny c-mdm2 genetika MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- uterus patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- MDM2 protein, human MeSH Prohlížeč
- protoonkogenní proteiny c-mdm2 MeSH
Leiomyomas with adipocytic differentiation typically occur in the uterus although they may arise at several sites in the female genital tract. While these are most commonly spindled leiomyomas with a component of adipocytic tissue ("conventional lipoleiomyomas"), there is a relatively ill-defined assortment of leiomyoma variants with adipocytic differentiation. We performed a morphologic, immunohistochemical and MDM2 gene amplification analysis of a large series of gynecologic leiomyomas with adipocytic differentiation to better define the clinicopathologic spectrum. Forty four tumors from 44 patients were identified and classified as conventional lipoleiomyoma (n = 21), adipocyte-rich lipoleiomyoma (defined as tumor volume >80 % adipocytes, n = 9); cellular lipoleiomyoma (n = 9); hydropic lipoleiomyoma (n = 3); and lipoleiomyoma with bizarre nuclei (n = 2). Patient age ranged from 32 to 83 years (mean 63; median 63). Primary location included uterine corpus (35), uterine cervix (3), uterine corpus/cervix (1), broad ligament (2), parametrium (2), and round ligament (1). Tumor size was 0.6-30 cm (mean 8; median 6). None of the 34 patients with follow up developed further disease (range 1-311 months; mean 65; median 41). Immunohistochemical expression of ER, PR, HMB45, Melan A, Cathepsin K and WT-1 in lipoleiomyomas and variants was similar to patterns in non-adipocytic gynecologic leiomyomas. MDM2 amplification fluorescence in situ hybridization performed on 14 tumors was negative in all. Our findings suggest female genital tract conventional lipoleiomyomas and lipoleiomyoma variants largely parallel their non-adipocytic counterparts in morphology and immunophenotype, and may be categorized using non-adipocytic leiomyoma histologic criteria.
Department of Laboratory Medicine and Pathology Mayo Clinic Jacksonville FL USA
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA
Department of Pathology Northwestern Medicine Central DuPage Hospital Winfield IL USA
Department of Pathology The Johns Hopkins Medical Institutions Baltimore MD USA
Department of Pathology University of Ostrava Faculty of Medicine Ostrava Czech Republic
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