Blood pressure control in hypertensive sleep apnoea patients of the European Sleep Apnea Database cohort - effects of positive airway pressure and antihypertensive medication
Status PubMed-not-MEDLINE Jazyk angličtina Země Velká Británie, Anglie Médium electronic-ecollection
Typ dokumentu časopisecké články
PubMed
38035035
PubMed Central
PMC10686603
DOI
10.1093/ehjopen/oead109
PII: oead109
Knihovny.cz E-zdroje
- Klíčová slova
- Antihypertensive treatment, ESADA, Hypertension, Obstructive sleep apnoea, Precision medicine,
- Publikační typ
- časopisecké články MeSH
AIMS: We analysed longitudinal blood pressure (BP) data from hypertensive obstructive sleep apnoea (OSA) patients in the European Sleep Apnea Database cohort. The study investigated the interaction between positive airway pressure (PAP)-induced BP change and antihypertensive treatment (AHT). METHODS AND RESULTS: Hypertensive patients with AHT [monotherapy/dual therapy n = 1283/652, mean age 59.6 ± 10.7/60.6 ± 10.3 years, body mass index (BMI) 34.2 ± 6.5/34.8 ± 7.0 kg/m2, apnoea-hypopnoea index 46 ± 25/46 ± 24 n/h, proportion female 29/26%, respectively] started PAP treatment. Office BP at baseline and 2- to 36-month follow-up were assessed. The interaction between AHT drug classes and PAP on BP was quantified and the influences of age, gender, BMI, co-morbidities, BP at baseline, and study site were evaluated. Following PAP treatment (daily usage, 5.6 ± 1.6/5.7 ± 1.9 h/day), systolic BP was reduced by -3.9 ± 15.5/-2.8 ± 17.7 mmHg in mono/dual AHT and diastolic BP by -3.0 ± 9.8/-2.7 ± 10.8 mmHg, respectively, all P < 0.0001. Systolic and diastolic BP control was improved following PAP treatment (38/35% to 54/46% and 67/67% to 79/74%, mono/dual AHT, respectively). PAP treatment duration predicted a larger BP improvement in the monotherapy group. Intake of renin-angiotensin blockers [angiotensin converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB)] alone or in any AHT combination was associated with better BP control. The AHT-dependent BP improvement was independent of confounders. CONCLUSION: In this pan-European OSA patient cohort, BP control improved following initiation of PAP. Longer PAP treatment duration, was associated with a favourable effect on BP. Our study suggests that ACEI/ARB, alone or in combination with other drug classes, provides a particularly strong reduction of BP and better BP control when combined with PAP in OSA.
Cardiology Unit Sleep Center IRCCS Istituto Auxologico Italiano Milan Italy
Department of Chest Diseases Ege University Izmir Turkey
Department of Internal Medicine University Hospital Brno Brno Czech Republic
Department of Medicine and Surgery University of Milano Bicocca Milan Italy
Department of Sleep Medicine Sahlgrenska University Hospital Blå stråket 5 413 45 Gothenburg Sweden
Sleep Disorders Center St Adolf Stift Reinbeck Germany
Sleep Disorders Centre University Hospital Gasthuisberg Leuven Belgium
Unità Operativa di Medicina del Sonno Istituto Scientifico di Pavia IRCCS Pavia Italy
Université Grenoble Alpes INSERM HP2 and Grenoble University Hospital Grenoble France
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