There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be validated. (1) A survey was conducted involving all members of the International Association of Pancreatology (IAP) to understand the characteristics of international discharge protocols. (2) We investigated the safety and effectiveness of the HPSG-discharge protocol. According to our international survey, 87.5% (49/56) of the centres had no discharge protocol. Patients discharged based on protocols have a significantly shorter median length of hospitalization (LOH) (7 (5;10) days vs. 8 (5;12) days) p < 0.001), and a lower rate of readmission due to recurrent AP episodes (p = 0.005). There was no difference in median discharge CRP level among the international cohorts (p = 0.586). HPSG-protocol resulted in the shortest LOH (6 (5;9) days) and highest median CRP (35.40 (13.78; 68.40) mg/l). Safety was confirmed by the low rate of readmittance (n = 35; 5%). Discharge protocol is necessary in AP. The discharge protocol used in this study is the first clinically proven protocol. Developing and testifying further protocols are needed to better standardize patients' care.

1st Department of Surgery University Hospital of L Pasteur Kosice Slovak Republic

4th Department of Surgery Medical School Aristotle University of Thessaloniki General Hospital George Papanikolaou Thessaloniki Greece

Borsod Abaúj Zemplén County Hospital and University Teaching Hospital Miskolc Hungary

Carol Davila University of Medicine and Pharmacy Bucharest Romania

Centre for Translational Medicine Semmelweis University Budapest Hungary

Centrum péče o zažívací trakt Vítkovická Nemocnice a s Ostrava Czech Republic

Clinic of Internal Medicine Gastroenterology JFM CU Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Bratislava Slovakia

Clinical Institute Fundeni Bucharest Romania

Collegium Medicum The Jan Kochanowski University in Kielce Kielce Poland

County Emergency Clinical Hospital of Târgu Mures Gastroenterology Clinic and University of Medicine Pharmacy Sciences and Technology George Emil Palade Targu Mures Romania

Department for Hepatobiliary and Pancreatic Surgery Clinic for General Surgery Military Medical Academy University of Defense Belgrade Serbia

Department for Surgery Hungarian Defence Forces Medical Centre Budapest Hungary

Department of Digestive Tract Diseases Medical University of Lodz Lodz Poland

Department of Emergency Medicine Medical School University of Pécs Pécs Hungary

Department of Gastroenterology 1st Affiliated Hospital of Nanchang University Nanchang China

Department of Gastroenterology BMKK Dr Rethy Pal Hospital Békéscsaba Hungary

Department of Gastroenterology Clinical Hospital Center Rijeka University of Rijeka Rijeka Croatia

Department of Gastroenterology Clinical Medical College Yangzhou University Yangzhou Jiangsu China

Department of Gastroenterology Faculty of Medicine Sakarya University Sakarya Turkey

Department of Gastroenterology Institute of Internal Medicine Faculty of Medicine University of Debrecen Debrecen Hungary

Department of Gastroenterology Medical University of Lodz Lodz Poland

Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India

Department of Gastroenterology Queen Yoanna University Hospital Medical University of Sofia Sofia Bulgaria

Department of Hepato Pancreato Biliary and Transplant Surgery Hospital Universitari Vall d'Hebron Universitat Autònoma de Barcelona Barcelona Spain

Department of Integrated Traditional Chinese and Western Medicine Sichuan Provincial Pancreatitis Center and West China Liverpool Biomedical Research Center West China Hospital Sichuan University Chengdu China

Department of Internal Medicine and Liver Research Institute Seoul National University Hospital Seoul Republic of Korea

Department of Internal Medicine and Surgery Alma Mater Studiorum University of Bologna S Orsola Malpighi Hospital Bologna Italy

Department of Internal Medicine Jeju National University College of Medicine Jeju South Korea

Department of Laboratory Medicine Medical School University of Pécs Pécs Hungary

Department of Laboratory Medicine Semmelweis University Budapest Hungary

Department of Medical Imaging Medical School University of Pécs Pécs Hungary

Department of Medicine 2 University Medical Center Mannheim Medical Faculty Mannheim Heidelberg University Mannheim Germany

Department of Medicine Gastroenterology The Pancreas Institute G B Rossi University Hospital Verona Italy

Department of Medicine University of Szeged Szeged Hungary

Department of Pathophysiology Clinical Pathophysiology Omsk State Medical University Omsk Russia

Department of Surgery and Urology Omsk State Medical University Omsk Russia

Department of Surgery AOU Sant'Orsola Malpighi IRCCS Azienda Ospedaliera Universitaria Bologna Italy

Department of Surgery Lithuanian University of Health Sciences Kaunas Lithuania

Department of Surgery University Hospital Stara Zagora Bulgaria

Department of Surgery With a Course of Emergency and Vascular Surgery Bogomolet National Medical University Kiev Ukraine

Department of Transplantation and Liver Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland

Discipline of Internal Medicine Diabetes Nutrition Metabolic Diseases and Systemic Rheumatology Victor Babeş University of Medicine and Pharmacy Timisoara Timisoara Romania

Division of Gastroenterology 1st Department of Medicine Medical School University of Pécs Pécs Hungary

Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University Anam Hospital Seoul Republic of Korea

Division of Gastroenterology Department of Internal Medicine Gachon University Gil Medical Center Gachon University College of Medicine Incheon Republic of Korea

Division of Gastroenterology University of Leipzig Medical Center Leipzig Germany

Division of Pancreatic Surgery IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy

Dr Bugyi István Hospital Szentes Hungary

Emergency Hospital of Bucharest Carol Davila University of Medicine and Pharmacy Bucharest Bucharest Romania

Exocrine Pancreas Research Unit Hospital Universitari Vall d'Hebron Institut de Recerca Universitat Autònoma de Barcelona CIBEREHD Barcelona Spain

Faculty of Medicine Ovidius University of Constanta Constanta Romania

Gastroenterology Department 4th Medical Clinic Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca Romania

Gastroenterology Department Colentina Clinical Hospital Bucharest Bucharest Romania

Gastroenterology Department Faculty of Medicine Mersin University Yenisehir Mersin Turkey

Gastroenterology Department Hospital da Senhora da Oliveira Guimarães Portugal

Gastroenterology Department University Hospital of Santiago de Compostela Santiago de Compostela Spain

General Surgery 1 Bogomolets National Medical University Kiev Ukraine

General Surgery Consorci Sanitari del Garraf Sant Pere de Ribes Barcelona Spain

General Surgery Department Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello Palermo Italy

Gomel State Medical University Gomel Belarus

Habib Bourguiba University Hospital Sfax Tunisia

Healthcare Center of County Csongrád Makó Hungary

Heim Pál National Pediatric Institute Budapest Hungary

Hepatology and Gastroenterology Department of Roosevelt Hospital Banska Bystrica Slovakia

Hospital of Bezmialem Vakif University School of Medicine Istanbul Turkey

ICVS 3B's PT Government Associate Laboratory Braga Guimarães Portugal

Institute for Translational Medicine Medical School University of Pécs Pécs Hungary

Institute of Pancreatic Diseases Semmelweis University Budapest Hungary

İzmir Katip Çelebi University Atatürk Training and Research Hospital Karabaglar Izmir Turkey

Kyiv City Clinical Emergency Hospital Kiev Ukraine

Life and Health Sciences Research Institute School of Medicine University of Minho Braga Guimarães Portugal

Liverpool University Hospitals NHS Foundation Trust Liverpool UK

LMU University Hospital LMU Munich Munich Germany

Lviv Regional Clinical Hospital Lviv Ukraine

Markusovszky University Teaching Hospital Szombathely Hungary

Marmara University Education and Training Hospital Istanbul Turkey

Medical Imaging Centre Department of Radiology Semmelweis University Budapest Hungary

Mohamed Ben Sassi Hospital Gabes Tunisia

MTA SE Cardiovascular Imaging Research Group Medical Imaging Centre Semmelweis University Budapest Hungary

Octavin Fodor Institute of Gastroenterology and Hepartology Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca Romania

Omsk State Medical Information Analytical Centre Omsk State Medical University Omsk Russia

Pándy Kálmán Hospital of Békés County Gyula Hungary

Peterfy Hospital Budapest Hungary

Saint Luke Clinical Hospital St Petersburg Russia

Sechenov University Moscow Russia

Servicio de Aparato Digestivo Hospital Clínico Universitario Valladolid Valladolid Spain

Sklifosovsky Institute for Clinical Medicine Sechenov 1st Moscow State Medical University Moscow Russia

Surgery Department Hospital Prof Ferndo Fonseca Amadora Portugal

Szent György University Teaching Hospital of Fejér County Székesfehérvár Hungary

Translational Pancreatology Research Group Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged Szeged Hungary

Unidade HBP Serviço de Cirurgia Geral Centro Hospitalar Tondela Viseu Viseu Portugal

University Hospital Arnau de Vilanova Hospital University Santa Maria Lleida Spain

University of Liverpool Liverpool University Hospitals NHS Foundation Trust Liverpool UK

Vilnius University Hospital Santariskiu Klinikos Vilnius Lithuania

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