Onosma riedliana Binzet & Orcan, a traditionally used plant species, has been explored for its therapeutic potential in this study. The work presented here is the first report on the phenolic profile and biological activity of this species. Three extracts of varying polarity were prepared, with the methanolic extract containing the highest phenolic content (97.62 ± 0.20 mgGAE/g). Key phenolic compounds identified included pinoresinol, hesperidin, 4-hydroxybenzoic acid, and p-coumaric acid. The methanolic extract exhibited exceptional antioxidant properties, rivaling Trolox as a positive control, primarily attributed to hesperidin and luteolin. Moreover, the ethyl acetate extract demonstrated remarkable inhibition of cholinesterase and tyrosinase enzymes, while the methanolic extract displayed potent activity against carbohydrate hydrolytic enzymes, α-amylase and α-glucosidase. Again, phenolic compounds were shown to be responsible for the inhibition of cholinesterases and tyrosinase, but not for α-amylase and α-glucosidase. These findings underscore Onosma riedliana's potential for incorporation into diverse pharmaceutical formulations, given its multifaceted bioactivity.

Centre of the Region Haná for Biotechnological and Agricultural Research Department of Genetic Re sources for Vegetables Medicinal and Special Plants Crop Research Institute Šlechtitelů 29 Olomouc 78371 Czech Republic

Czech Advanced Technology and Research Institute Palacky University Šlechtitelů 27 Olomouc 78371 Czech Republic

Faculty of Arts and Science Department of Biology Mersin University Mersin TR 33343 Turkey

Faculty of Pharmacy Afyonkarahisar Health Sciences University Afyonkarahisar TR 03100 Turkey

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Kumar N, Goel N. Phenolic acids: natural versatile molecules with promising therapeutic applications. Biotechnol Rep. 2019;24:e00370. doi: 10.1016/j.btre.2019.e00370. PubMed DOI PMC

Binzet R, Orcan N (2007) A new species of Onosma (Boraginaceae) from Southern Turkey. Novon 17:8–10. 10.3417/1055-3177(2007)17[8:ANSOOB]2.0.CO;2

Naikoo MI, Dar MI, Raghib F, Jaleel H, Ahmad B, Raina A, Khan FA, Naushin F (2019) Role and regulation of plants phenolics in abiotic stress tolerance: an overview. In: Plant Signaling Molecules. Khan MIR, Reddy PS, Ferrante A, Khan NA. (Eds). Woodhead Publishing, pp. 157–168. 10.1016/B978-0-12-816451-8.00009-5

Kumar N, Kumar R, Kishore K (2013) Onosma L.: A review of phytochemistry and ethnopharmacology. Pharmacogn Rev 7:140–151. 10.4103/0973-7847.120513 PubMed PMC

Baltaci N, Aydogdu N, Sarikurkcu C, Tepe B (2021) Onosma gracilis (Trautv.) and O. oreodoxa (Boiss. & Heldr.): Phytochemistry, in silico docking, antioxidant and enzyme inhibitory activities. S Af J Bot 143:410–417. 10.1016/j.sajb.2021.03.022

Kirkan B, Sarikurkcu C, Zengin G. Bioactive constituents, antioxidant effects and enzyme inhibitory properties of two Onosma species (Onosma Trapezuntea and O. Rigidum) S Af J Bot. 2022;145:142–148. doi: 10.1016/j.sajb.2021.09.036. DOI

Kirkan B, Sarikurkcu C, Binzet R, Tepe B (2023) Two Onosma species (Onosma microcarpum and O. nana) as an alternative source of multifunctional agents: biological and phytochemical evaluation. Biointerface Res. Appl. Chem. 13:77. 10.33263/BRIAC131.077

Kirkan B, Sarikurkcu C, Ozer MS, Cengiz M, Atılgan N, Ceylan O, Tepe B (2018) Phenolic profile, antioxidant and enzyme inhibitory potential of Onosma tauricum var. tauricum. Ind Crop Prod 125:549–555. 10.1016/j.indcrop.2018.09.043

Saravanakumar K, Sarikurkcu C, Sahinler SS, Sarikurkcu RB, Wang M-H. Phytochemical composition, antioxidant, and enzyme inhibition activities of methanolic extracts of two endemic Onosma species. Plants. 2021;10:1373. doi: 10.3390/plants10071373. PubMed DOI PMC

Saravanakumar K, Sarikurkcu C, Sarikurkcu RT, Wang M-H. A comparative study on the phenolic composition, antioxidant and enzyme inhibition activities of two endemic Onosma species. Ind Crop Prod. 2019;142:111878. doi: 10.1016/j.indcrop.2019.111878. DOI

Sarikurkcu C, Kirkan B, Ozer MS, Ceylan O, Atilgan N, Cengiz M, Tepe B. Chemical characterization and biological activity of Onosma gigantea extracts. Ind Crop Prod. 2018;115:323–329. doi: 10.1016/j.indcrop.2018.02.040. DOI

Sarikurkcu C, Sahinler SS, Ceylan O, Tepe B. Onosma pulchra: phytochemical composition, antioxidant, skin-whitening and anti-diabetic activity. Ind Crop Prod. 2020;154:112632. doi: 10.1016/j.indcrop.2020.112632. DOI

Sarikurkcu C, Sahinler SS, Tepe B (2020) Onosma aucheriana, O. frutescens, and O. sericea: phytochemical profiling and biological activity. Ind Crop Prod 154:112633. 10.1016/j.indcrop.2020.112633

Sarikurkcu C, Sahinler SS, Husunet MT, Istifli ES, Tepe B (2020) Two endemic Onosma species (O. sieheana and O. stenoloba): A comparative study including docking data on biological activity and phenolic composition. Ind Crop Prod 154:112656. 10.1016/j.indcrop.2020.112656

Sarikurkcu C, Sahinler SS, Ceylan O, Tepe B. Onosma ambigens: phytochemical composition, antioxidant and enzyme inhibitory activity. Ind Crop Prod. 2020;154:112651. doi: 10.1016/j.indcrop.2020.112651. DOI

Tlili N, Sarikurkcu RT, Ceylan O, Sarikurkcu C (2020) Onosma polyantha vs. Onosma mollis: analysis of phenolic compounds using liquid chromatography–electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) and assessment of the antioxidant activity. Anal Lett 1–12. 10.1080/00032719.2020.1803348

Bayram B, Esatbeyoglu T, Schulze N, Ozcelik B, Frank J, Rimbach G. Comprehensive analysis of polyphenols in 55 extra virgin olive oils by HPLC-ECD and their correlation with antioxidant activities. Plant Foods Hum Nutr. 2012;67:326–336. doi: 10.1007/s11130-012-0315-z. PubMed DOI

Zhou H, Ren J, Li Z (2017) Antibacterial activity and mechanism of pinoresinol from Cinnamomum camphora leaves against food-related bacteria. Food Control 79:192–199. 10.1016/j.foodcont.2017.03.041

Wikul A, Damsud T, Kataoka K, Phuwapraisirisan P. (+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibiting α-glucosidase. Bioorg Med Chem Lett. 2012;22:5215–5217. doi: 10.1016/j.bmcl.2012.06.068. PubMed DOI

Sun T, Tanumihardjo SA. An integrated approach to evaluate food antioxidant capacity. J Food Sci. 2007;72:R159–R165. doi: 10.1111/j.1750-3841.2007.00552.x. PubMed DOI