Influence of environmental enrichment on sexual behavior and the process of learning and memory in a rat model of autism with valproic acid
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
38142724
DOI
10.1016/j.brainres.2023.148738
PII: S0006-8993(23)00509-7
Knihovny.cz E-zdroje
- Klíčová slova
- Autism, Enriched environment, Morris water maze test, Recognition memory test, Sexual behavior, Valproic acid,
- MeSH
- autistická porucha * chemicky indukované MeSH
- krysa rodu Rattus MeSH
- kyselina valproová škodlivé účinky MeSH
- lidé MeSH
- poruchy autistického spektra * chemicky indukované MeSH
- sexuální chování MeSH
- těhotenství MeSH
- zpožděný efekt prenatální expozice * chemicky indukované MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- lidé MeSH
- mužské pohlaví MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- kyselina valproová MeSH
Autism spectrum disorder (ASD) is a psychiatric disorder with severe behavioral consequences and no specific therapy. Its etiology is multifactorial, as it is caused by a complex interaction of genetic and environmental factors. In rats, prenatal exposure to the antiepileptic drug valproic acid (VPA) has been associated with an increased risk of autistic-like behaviors in offspring, including social behavior deficits, increased repetitive behaviors, and cognitive impairments. In addition, VPA-treated rats have shown altered sociosexual behaviors. However, the mechanisms underlying these alterations in reproductive processes in VPA-treated rats are not fully understood. Interestingly some abnormal behaviors in VPA autism models are improved by an enriched environment (EE). In the present study, we examined the effects of EE on memory performance and sexual behavior in male rats. We found that on postnatal day 90, EE reduced the time it took for both control and VPA-treated groups to find a hidden platform in the Morris water maze. On PND 100, prenatal exposure to VPA reduced total exploring time in object recognition tests. On PND 110, EE reduced mount and intromission latency and increased ejaculatory frequency in VPA-treated male rats. These results suggest that environmental stimuli significantly influence the onset of sexual behavior in VPA-treated male rats and that EE may be a potential tool for improving a variety of behavioral deficiencies in rodent models of autism.
Centro Tlaxcala Biología de la Conducta Universidad Autónoma de Tlaxcala Tlaxcala México
Facultad de Ciencias para el Desarrollo Humano Universidad Autónoma de Tlaxcala Tlaxcala México
Citace poskytuje Crossref.org
