Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Air pollution and molecular changes in age-related diseases

B. Hermanova, P. Riedlova, A. Dalecka, V. Jirik, V. Janout, RJ. Sram

. 2022 ; 32 (4) : 772-790. [pub] 20200729

Language English Country Great Britain

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc22010704

Assessment of the impact that air contaminants have on health is difficult as this is a complex mixture of substances that varies depending on the time and place. There are many studies on the association between air pollution and increased morbidity and mortality. Before the effect of polluted air is manifested at the level of the organs, an impact can be observed at the molecular level. These include some new biomarkers, like a shortening of the mean telomere length in DNA, dysregulation of gene expression caused by microRNA levels or a variation in the copy number of mitochondrial DNA. These changes may predispose individuals to premature development of age-related diseases and consequently to shortening of life. The common attribute, shared by changes at the molecular level and the development of diseases, is the presence of oxidative stress.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22010704
003      
CZ-PrNML
005      
20220506125950.0
007      
ta
008      
220425s2022 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1080/09603123.2020.1797643 $2 doi
035    __
$a (PubMed)32723182
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Hermanova, B $u Centre for Epidemiological Research, University of Ostrava, Ostrava, Czech Republic $u Department of Epidemiology and Public Health, University of Ostrava, Ostrava, Czech Republic $1 https://orcid.org/0000000190573192
245    10
$a Air pollution and molecular changes in age-related diseases / $c B. Hermanova, P. Riedlova, A. Dalecka, V. Jirik, V. Janout, RJ. Sram
520    9_
$a Assessment of the impact that air contaminants have on health is difficult as this is a complex mixture of substances that varies depending on the time and place. There are many studies on the association between air pollution and increased morbidity and mortality. Before the effect of polluted air is manifested at the level of the organs, an impact can be observed at the molecular level. These include some new biomarkers, like a shortening of the mean telomere length in DNA, dysregulation of gene expression caused by microRNA levels or a variation in the copy number of mitochondrial DNA. These changes may predispose individuals to premature development of age-related diseases and consequently to shortening of life. The common attribute, shared by changes at the molecular level and the development of diseases, is the presence of oxidative stress.
650    _2
$a stárnutí $7 D000375
650    12
$a látky znečišťující vzduch $x analýza $x toxicita $7 D000393
650    12
$a znečištění ovzduší $x škodlivé účinky $x analýza $7 D000397
650    _2
$a lidé $7 D006801
650    12
$a mikro RNA $7 D035683
650    _2
$a pevné částice $x analýza $7 D052638
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Riedlova, P $u Centre for Epidemiological Research, University of Ostrava, Ostrava, Czech Republic $u Department of Epidemiology and Public Health, University of Ostrava, Ostrava, Czech Republic $1 https://orcid.org/0000000175826307
700    1_
$a Dalecka, A $u Centre for Epidemiological Research, University of Ostrava, Ostrava, Czech Republic $u Department of Epidemiology and Public Health, University of Ostrava, Ostrava, Czech Republic $1 https://orcid.org/0000000298087444
700    1_
$a Jirik, V $u Centre for Epidemiological Research, University of Ostrava, Ostrava, Czech Republic $u Department of Epidemiology and Public Health, University of Ostrava, Ostrava, Czech Republic $1 https://orcid.org/0000000183874077 $7 mzk2007381919
700    1_
$a Janout, V $u Centre for Epidemiological Research, University of Ostrava, Ostrava, Czech Republic $1 https://orcid.org/0000000211630361 $7 jn20010524003
700    1_
$a Sram, R J $u Centre for Epidemiological Research, University of Ostrava, Ostrava, Czech Republic $1 https://orcid.org/0000000225004572
773    0_
$w MED00002315 $t International journal of environmental health research $x 1369-1619 $g Roč. 32, č. 4 (2022), s. 772-790
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32723182 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220425 $b ABA008
991    __
$a 20220506125943 $b ABA008
999    __
$a ok $b bmc $g 1788713 $s 1161902
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 32 $c 4 $d 772-790 $e 20200729 $i 1369-1619 $m International journal of environmental health research $n Int J Environ Health Res $x MED00002315
LZP    __
$a Pubmed-20220425

Find record

Citation metrics

Archiving options