Nanoceria is a promising nanomaterial for the catalytic hydrolysis of a wide variety of substances. In this study, it was experimentally demonstrated for the first time that CeO2 nanostructures show extraordinary reactivity toward sulfonamide drugs (sulfadimethoxine, sulfamerazine, and sulfapyridine) in aqueous solution without any illumination, activation, or pH adjustment. Hydrolytic cleavage of various bonds, including S-N, C-N, and C-S, was proposed as the main reaction mechanism and was indicated by the formation of various reaction products, namely, sulfanilic acid, sulfanilamide, and aniline, which were identified by HPLC-DAD, LC-MS/MS, and NMR spectroscopy. The kinetics and efficiency of the ceria-catalyzed hydrolytic cleavage were dependent on the structure of the sulfonamide molecule and physicochemical properties of Nanoceria prepared by three different precipitation methods. However, in general, all three ceria samples were able to cleave SA drugs tested, proving the robust and unique surface reactivity toward these compounds inherent to cerium dioxide. The demonstrated reactivity of CeO2 to molecules containing sulfonamide or even sulfonyl (and similar) functional groups may be significant for both heterogeneous catalysis and environmentally important degradation reactions.

Faculty of Environment Jan Evangelista Purkyně University in Ústí nad Labem Pasteurova 3632 15 400 96 Ústí nad Labem Czechia

Faculty of Science Jan Evangelista Purkyně University in Ústí nad Labem Pasteurova 3632 15 400 96 Ústí nad Labem Czechia

Institute of Inorganic Chemistry of the Czech Academy of Sciences 250 68 Husinec Řež Czechia

Institute of Physics of the Czech Academy of Sciences Cukrovarnická 10 162 00 Prague Czechia

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