Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases and conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, and patient noncompliance. To tackle these issues, novel topical and transdermal platforms involving nanotechnology have been developed. This review focuses on the latest advances regarding the development of nanoemulgels for skin application, encapsulating a wide variety of molecules, including already marketed drugs (miconazole, ketoconazole, fusidic acid, imiquimod, meloxicam), repurposed marketed drugs (atorvastatin, omeprazole, leflunomide), natural-derived compounds (eucalyptol, naringenin, thymoquinone, curcumin, chrysin, brucine, capsaicin), and other synthetic molecules (ebselen, tocotrienols, retinyl palmitate), for wound healing, skin and skin appendage infections, skin inflammatory diseases, skin cancer, neuropathy, or anti-aging purposes. Developed formulations revealed adequate droplet size, PDI, viscosity, spreadability, pH, stability, drug release, and drug permeation and/or retention capacity, having more advantageous characteristics than current marketed formulations. In vitro and/or in vivo studies established the safety and efficacy of the developed formulations, confirming their therapeutic potential, and making them promising platforms for the replacement of current therapies, or as possible adjuvant treatments, which might someday effectively reach the market to help fight highly incident skin or systemic diseases and conditions.

CICS UBI Health Sciences Research Centre University of Beira Interior 6201 001 Covilhã Portugal

Faculty of Pharmacy Masaryk University Palackého tř 1946 Brno Královo Pole 612 00 Brno Czech Republic

Faculty of Pharmacy University of Coimbra Azinhaga de Santa Comba 3000 548 Coimbra Portugal

Faculty of Pharmacy University of Ljubljana Aškerčeva c 7 1000 Ljubljana Slovenia

REQUIMTE LAQV Group of Pharmaceutical Technology Faculty of Pharmacy University of Coimbra 3000 548 Coimbra Portugal

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