Immunotoxicity of stainless-steel nanoparticles obtained after 3D printing
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
38350218
DOI
10.1016/j.ecoenv.2024.116088
PII: S0147-6513(24)00163-5
Knihovny.cz E-zdroje
- Klíčová slova
- 3D printing, Immunotoxicity, Metal alloy powders, Selective laser melting,
- MeSH
- 3D tisk MeSH
- cytokiny MeSH
- kovy MeSH
- lidé MeSH
- nanočástice * toxicita MeSH
- nerezavějící ocel * farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- cytokiny MeSH
- kovy MeSH
- nerezavějící ocel * MeSH
This study aims to investigate the in vitro effects of nanoparticles (NPs) produced during the selective laser melting (SLM) of 316 L stainless steel metal powder on the immune response in a human blood model. Experimental data did not reveal effect on viability of 316 L NPs for the tested doses. Functional immune assays showed a significant immunosuppressive effect of NPs. There was moderate stimulation (117%) of monocyte phagocytic activity without significant changes in phagocytic activity and respiratory burst of granulocytes. A significant dose-dependent increase in the levels of the pro-inflammatory cytokine TNF-a was found in blood cultures treated with NPs. On the contrary, IL-8 chemokine levels were significantly suppressed. The levels of the pro-inflammatory cytokine IL-6 were reduced by only a single concentration of NPs. These new findings can minimise potential health risks and indicate the need for more research in this area.
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