Preoperative and postoperative staging in endometrial cancer - a prospective study
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
38418246
DOI
10.48095/cccg20245
PII: 136565
Knihovny.cz E-resources
- Keywords
- endometrial cancer, sentinel lymph node detection, tumour grade, tumour stage,
- MeSH
- Sentinel Lymph Node Biopsy methods MeSH
- Humans MeSH
- Lymph Node Excision methods MeSH
- Lymph Nodes pathology MeSH
- Endometrial Neoplasms * surgery pathology MeSH
- Prospective Studies MeSH
- Sentinel Lymph Node * pathology MeSH
- Neoplasm Staging MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
OBJECTIVE: The aim of this study was to determine how often changes the stage of the tumour in definitive histology against preoperative clinical stage in patient cohort with diagnosed endometrial cancer. METHODS: We evaluated prospectively a cohort of 166 patients with endometrial cancer. They all underwent abdominal hysterectomy, bilateral salpingo-oophorectomy, sentinel lymph node biopsy. Patients with high-risk tumours also pelvic lymfadenectomy. We collected data of preoperative diagnostic biopsy and postoperative definitive histology. The data were statistically processed. RESULTS: Detection of sentinel lymph node was successful in 71.1%, bilateral successful detection was in 40.6%. Discrepancy of tumour grade between preoperative biopsy and definitive histology was generally 31.4%. Upgrading of the tumour was in 22 (14.4%) cases, downgrading in 26 (17%) cases. Upgrade from low-risk to high-risk group of tumours was noticed in eight cases. Histopathological tumour type changed in 6.6%, 4.6% moved to histopathologic high-risk group. The tumour stage changed in definite histology in 57.3%, in 19.2% of cases moved from stage low/intermediate-risk group to intermediate-high/high-risk disease group. CONCLUSION: Correct assessment of preoperative clinical stage and histological grade of endometrial cancer is burdened with a high inaccuracy rate. A lot of cases is up-staged after surgical staging and moved to intermediate-high/high-risk disease group. Results confirm the importance of oncogynaecologic centre II. evaluation of histopathology findings from diagnostic biopsies made in referring hospitals. Sentinel lymph node biopsy should be performed even in clinically low/intermediate-risk disease group.
References provided by Crossref.org
New FIGO 2023 Staging System of Endometrial Cancer: An Updated Review on a Current Hot Topic