No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
38511853
PubMed Central
PMC11363458
DOI
10.1177/13524585241240406
Knihovny.cz E-zdroje
- Klíčová slova
- Multiple sclerosis, disease severity, genetics,
- MeSH
- dospělí MeSH
- genotyp MeSH
- jednonukleotidový polymorfismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- registrace * MeSH
- relabující-remitující roztroušená skleróza * genetika MeSH
- roztroušená skleróza genetika MeSH
- stupeň závažnosti nemoci * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. METHODS: We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. RESULTS: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05). CONCLUSION: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.
Department of Neurology Alfred Health Melbourne VIC Australia
Department of Neurology John Hunter Hospital Newcastle NSW Australia
Hospital Universitario Virgen Macarena Sevilla Spain
Instituto de Parasitología y Biomedicina López Neyra CSIC Granada Spain
Menzies Institute for Medical Research University of Tasmania Hobart TAS Australia
School of Medicine and Public Health The University of Newcastle Newcastle NSW Australia
Zobrazit více v PubMed
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Butzkueven H, Chapman J, Cristiano E, et al.. MSBase: An international, online registry and platform for collaborative outcomes research in multiple sclerosis. Mult Scler 2006; 12(6): 769–774. PubMed
Kreft KL, Uzochukwu E, Loveless S, et al.. Relevance of multiple sclerosis severity genotype in predicting disease course: A real-world cohort. Ann Neurol 2024; 95(3): 459–470. PubMed
