No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
PubMed
38511853
PubMed Central
PMC11363458
DOI
10.1177/13524585241240406
Knihovny.cz E-resources
- Keywords
- Multiple sclerosis, disease severity, genetics,
- MeSH
- Adult MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide MeSH
- Middle Aged MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Registries * MeSH
- Multiple Sclerosis, Relapsing-Remitting * genetics MeSH
- Multiple Sclerosis genetics MeSH
- Severity of Illness Index * MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. METHODS: We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. RESULTS: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05). CONCLUSION: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.
Department of Neurology Alfred Health Melbourne VIC Australia
Department of Neurology John Hunter Hospital Newcastle NSW Australia
Hospital Universitario Virgen Macarena Sevilla Spain
Instituto de Parasitología y Biomedicina López Neyra CSIC Granada Spain
Menzies Institute for Medical Research University of Tasmania Hobart TAS Australia
School of Medicine and Public Health The University of Newcastle Newcastle NSW Australia
See more in PubMed
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