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No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry

. 2024 Aug ; 30 (9) : 1216-1220. [epub] 20240321

Language English Country England, Great Britain Media print-electronic

Document type Journal Article

BACKGROUND: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. METHODS: We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. RESULTS: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05). CONCLUSION: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.

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Harroud A, Stridh P, McCauley JL, et al.. Locus for severity implicates CNS resilience in progression of multiple sclerosis. Nature 2023; 619(7969): 323–331. PubMed PMC

Jokubaitis VG, Campagna MP, Ibrahim O, et al.. Not all roads lead to the immune system: The genetic basis of multiple sclerosis severity. Brain 2023; 146(6): 2316–2331. PubMed

Butzkueven H, Chapman J, Cristiano E, et al.. MSBase: An international, online registry and platform for collaborative outcomes research in multiple sclerosis. Mult Scler 2006; 12(6): 769–774. PubMed

Kreft KL, Uzochukwu E, Loveless S, et al.. Relevance of multiple sclerosis severity genotype in predicting disease course: A real-world cohort. Ann Neurol 2024; 95(3): 459–470. PubMed

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