Stimuli-responsive thin film composites of conducting polymers and cellulose nanocrystals for tissue engineering
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
38518940
DOI
10.1016/j.ijbiomac.2024.131036
PII: S0141-8130(24)01841-5
Knihovny.cz E-zdroje
- Klíčová slova
- Cellulose nanocrystals, Human induced pluripotent stem cells, Poly(3,4-ethylenedioxythiophene), Polypyrrole,
- MeSH
- celulosa chemie MeSH
- indukované pluripotentní kmenové buňky * MeSH
- lidé MeSH
- nanočástice * MeSH
- polymery chemie MeSH
- prospektivní studie MeSH
- pyrroly chemie MeSH
- tkáňové inženýrství MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- celulosa MeSH
- polymery MeSH
- pyrroly MeSH
Thin composite films comprising two primary representatives of conducting polymers, poly(3, 4-ethylenedioxythiophene) (PEDOT) and polypyrrole (PPy), with eco-friendly cellulose nanocrystals (CNC) were prepared through electrochemical polymerization. The combination of CNC and PEDOT (or PPy) results in the formation of films with highly different surface topography and thickness. Intriguingly, different surface conductivity of PEDOT and PPy was revealed by atomic force microscopy albeit that the electrochemical properties were rather similar. The biological properties of the composites in contact with prospective human induced pluripotent stem cells (hiPSC) and cardiomyocytes derived from hiPSC demonstrated good cytocompatibility of both composites and their potential in engineering of electro-sensitive tissues. The as-prepared conducting, eco-friendly and cytocompatible composites are thus promising candidates for biomedical applications where stimuli-responsivity is a crucial cell-instructive property.
Citace poskytuje Crossref.org
