Stimuli-responsive thin film composites of conducting polymers and cellulose nanocrystals for tissue engineering
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
38518940
DOI
10.1016/j.ijbiomac.2024.131036
PII: S0141-8130(24)01841-5
Knihovny.cz E-resources
- Keywords
- Cellulose nanocrystals, Human induced pluripotent stem cells, Poly(3,4-ethylenedioxythiophene), Polypyrrole,
- MeSH
- Cellulose chemistry MeSH
- Induced Pluripotent Stem Cells * MeSH
- Humans MeSH
- Nanoparticles * MeSH
- Polymers chemistry MeSH
- Prospective Studies MeSH
- Pyrroles chemistry MeSH
- Tissue Engineering MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cellulose MeSH
- Polymers MeSH
- Pyrroles MeSH
Thin composite films comprising two primary representatives of conducting polymers, poly(3, 4-ethylenedioxythiophene) (PEDOT) and polypyrrole (PPy), with eco-friendly cellulose nanocrystals (CNC) were prepared through electrochemical polymerization. The combination of CNC and PEDOT (or PPy) results in the formation of films with highly different surface topography and thickness. Intriguingly, different surface conductivity of PEDOT and PPy was revealed by atomic force microscopy albeit that the electrochemical properties were rather similar. The biological properties of the composites in contact with prospective human induced pluripotent stem cells (hiPSC) and cardiomyocytes derived from hiPSC demonstrated good cytocompatibility of both composites and their potential in engineering of electro-sensitive tissues. The as-prepared conducting, eco-friendly and cytocompatible composites are thus promising candidates for biomedical applications where stimuli-responsivity is a crucial cell-instructive property.
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