meso-methyl-BODIPY photocages release a leaving group upon visible light irradiation but often lack thermal stability. In turn, our thermally-stable, red-shifted BODIPY phototether allows oligonucleotide cyclization, preventing complementary strand hybridization. Hybridization resumes upon red-NIR irradiation, disconnecting the phototether by oxidative cleavage, which is easily monitored by a blue shift in fluorescence.

Department of Organic Chemistry University of Chemistry and Technology Prague 166 28 Prague 6 Czech Republic

Goethe Universität Frankfurt Max von Laue Strasse 7 Frankfurt am Main 60438 Germany

Institute of Organic Chemistry and Biochemistry Flemingovo náměstí 542 Prague 160 00 Czech Republic

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