Mixed anxiety-depressive disorder in Parkinson's disease associated with worse resting state functional response to deep brain stimulation of subthalamic nucleus

. 2024 May 30 ; 10 (10) : e30698. [epub] 20240506

Status PubMed-not-MEDLINE Jazyk angličtina Země Velká Británie, Anglie Médium electronic-ecollection

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid38778942
Odkazy

PubMed 38778942
PubMed Central PMC11109721
DOI 10.1016/j.heliyon.2024.e30698
PII: S2405-8440(24)06729-X
Knihovny.cz E-zdroje

BACKGROUND: Parkinson's disease (PD), even though generally perceived as a dominantly motor disorder, is associated with a wide range of non-motor symptoms, including mixed anxiety-depressive disorder (MADD). OBJECTIVES: The aim of the presented study was to determine whether deep brain stimulation (DBS) of the subthalamic nucleus (STN) brings the functional characteristics of non-motor networks closer to the condition detected in healthy population and whether pre-DBS presence of MADD in PD patients was associated with different reaction to this therapeutic modality. METHODS: Resting-state fMRI signature elicited by STN DBS activation and deactivation in 81 PD patients was compared against healthy controls, with the focus on measures of efficiency of information processing and localised subnetwork differences. RESULTS: While all the MRI metrics showed statistically significant differences between PD patients in DBS OFF condition and healthy controls, none were detected in such a comparison against DBS ON condition. Furthermore, in the post-DBS evaluation, PD patients with MADD in the pre-DBS stage showed no differences in depression scales compared to pre-DBS psychiatrically intact PD patients, but still exhibited lower DBS-related connectivity in a subnetwork encompassing anterior and posterior cingulate, dorsolateral prefrontal and medial temporal cortices. CONCLUSIONS: STN DBS improved all the metrics of interest towards the healthy state, normalising the resting-state MRI signature of PD. Furthermore, pre-DBS presence of MADD, even though clinically silent at post-DBS MRI acquisition, was associated with lower DBS effect in areas highly relevant for depression. This finding points to a possibly latent nature of post-DBS MADD, calling for caution in further follow-up of these patients.

Zobrazit více v PubMed

O'Sullivan S.S., Williams D.R., Gallagher D.A., Massey L.A., Silveira-Moriyama L., Lees A.J. Nonmotor symptoms as presenting complaints in Parkinson's disease: a clinicopathological study. Mov. Disord. 2008;23:101–106. PubMed

Menza M.A., Robertson-Hoffman D.E., Bonapace A.S. Parkinson's disease and anxiety: comorbidity with depression, Biol. Psychiatry. 1993;34:465–470. PubMed

Walsh K., Bennett G. Parkinson's disease and anxiety. Postgrad. Med. J. 2001;77:89–93. PubMed PMC

Karlsen K.H., Tandberg E., Årsland D., Larsen J.P. Health related quality of life in Parkinson's disease: a prospective longitudinal study. J. Neurol. Neurosurg. Psychiatry. 2000;69:584–589. PubMed PMC

Aarsland D., Påhlhagen S., Ballard C.G., Ehrt U., Svenningsson P. Depression in Parkinson disease—epidemiology, mechanisms and management. Nat. Rev. Neurol. 2012;8:35–47. PubMed

Alexander G.E., DeLong M.R., Strick P.L. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 1986;9:357–381. PubMed

Mayberg H.S., Solomon D.H. Depression in Parkinson's disease: a biochemical and organic viewpoint. Adv. Neurol. 1995;65:49–60. PubMed

Matsui H., Nishinaka K., Oda M., Komatsu K., Kubori T., Udaka F. Minor depression and brain perfusion images in Parkinson's disease. Mov. Disord. Off. J. Mov. Disord. Soc. 2006;21:1169–1174. PubMed

Wang L., Hermens D.F., Hickie I.B., Lagopoulos J. A systematic review of resting-state functional-MRI studies in major depression. J. Affect. Disord. 2012;142:6–12. PubMed

Voon V., Krack P., Lang A.E., Lozano A.M., Dujardin K., Schüpbach M., D'Ambrosia J., Thobois S., Tamma F., Herzog J. A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease. Brain. 2008;131:2720–2728. PubMed PMC

Combs H.L., Folley B.S., Berry D.T., Segerstrom S.C., Han D.Y., Anderson-Mooney A.J., Walls B.D., van Horne C. Cognition and depression following deep brain stimulation of the subthalamic nucleus and globus pallidus pars internus in Parkinson's disease: a meta-analysis. Neuropsychol. Rev. 2015;25:439–454. PubMed

Nambu A., Chiken S. Deep Brain Stimul. Neurol. Disord. Springer; 2015. Mechanism of DBS: inhibition, excitation, or disruption? pp. 13–20.

Postuma R.B., Berg D., Stern M., Poewe W., Olanow C.W., Oertel W., Obeso J., Marek K., Litvan I., Lang A.E. MDS clinical diagnostic criteria for Parkinson's disease. Mov. Disord. 2015;30:1591–1601. PubMed

Goetz C.G., Tilley B.C., Shaftman S.R., Stebbins G.T., Fahn S., Martinez-Martin P., Poewe W., Sampaio C., Stern M.B., Dodel R. Movement disorder society-sponsored revision of the unified Parkinson's disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov. Disord. Off. J. Mov. Disord. Soc. 2008;23:2129–2170. PubMed

Hentz J.G., Mehta S.H., Shill H.A., Driver-Dunckley E., Beach T.G., Adler C.H. Simplified conversion method for unified Parkinson's disease rating scale motor examinations. Mov. Disord. 2015;30:1967–1970. PubMed PMC

Horn A., Kühn A.A. Lead-DBS: a toolbox for deep brain stimulation electrode localizations and visualizations. Neuroimage. 2015;107:127–135. PubMed

Glasser M.F., Sotiropoulos S.N., Wilson J.A., Coalson T.S., Fischl B., Andersson J.L., Xu J., Jbabdi S., Webster M., Polimeni J.R. The minimal preprocessing pipelines for the Human Connectome Project. Neuroimage. 2013;80:105–124. PubMed PMC

Smith S.M., Beckmann C.F., Andersson J., Auerbach E.J., Bijsterbosch J., Douaud G., Duff E., Feinberg D.A., Griffanti L., Harms M.P. Resting-state fMRI in the human connectome project. Neuroimage. 2013;80:144–168. PubMed PMC

Glasser M.F., Coalson T.S., Robinson E.C., Hacker C.D., Harwell J., Yacoub E., Ugurbil K., Andersson J., Beckmann C.F., Jenkinson M. A multi-modal parcellation of human cerebral cortex. Nature. 2016;536:171–178. PubMed PMC

Filip P., Jech R., Fečíková A., Havránková P., R\uužička F., Mueller K., Urgošík D. Restoration of functional network state towards more physiological condition as the correlate of clinical effects of pallidal deep brain stimulation in dystonia. Brain Stimulat. 2022;15:1269–1278. PubMed

Rubinov M., Sporns O. Complex network measures of brain connectivity: uses and interpretations. Neuroimage. 2010;52:1059–1069. doi: 10.1016/j.neuroimage.2009.10.003. PubMed DOI

Winkler A.M., Ridgway G.R., Webster M.A., Smith S.M., Nichols T.E. Permutation inference for the general linear model. Neuroimage. 2014;92:381–397. doi: 10.1016/j.neuroimage.2014.01.060. PubMed DOI PMC

Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B Methodol. 1995;57:289–300.

Jech R., Mueller K. Connect. Deep Brain Stimul. Elsevier; 2022. Investigating network effects of DBS with fMRI; pp. 275–301.

Marrelec G., Daunizeau J., Pelegrini-Issac M., Doyon J., Benali H. Conditional correlation as a measure of mediated interactivity in fMRI and MEG/EEG. IEEE Trans. Signal Process. 2005;53:3503–3516. doi: 10.1109/TSP.2005.853211. DOI

Cai J., Liu A., Mi T., Garg S., Trappe W., McKeown M.J., Wang Z.J. Dynamic graph theoretical analysis of functional connectivity in Parkinson's disease: the importance of fiedler value. IEEE J. Biomed. Health Inform. 2019;23:1720–1729. doi: 10.1109/JBHI.2018.2875456. PubMed DOI

Guan X., Zhang Y., Wei H., Guo T., Zeng Q., Zhou C., Wang J., Gao T., Xuan M., Gu Q., Xu X., Huang P., Pu J., Zhang B., Liu C., Zhang M. Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease. Neurobiol. Aging. 2019;75:83–97. doi: 10.1016/j.neurobiolaging.2018.11.013. PubMed DOI PMC

Bullmore E., Sporns O. The economy of brain network organization. Nat. Rev. Neurosci. 2012;13:336–349. doi: 10.1038/nrn3214. PubMed DOI

Lehto L.J., Filip P., Laakso H., Sierra A., Slopsema J.P., Johnson M.D., Eberly L.E., Low W.C., Gröhn O., Tanila H., Mangia S., Michaeli S. Tuning neuromodulation effects by orientation selective deep brain stimulation in the rat medial frontal cortex. Front. Neurosci. 2018 doi: 10.3389/fnins.2018.00899. 0. PubMed DOI PMC

Ulla M., Thobois S., Llorca P.-M., Derost P., Lemaire J.-J., Chereau-Boudet I., De Chazeron I., Schmitt A., Ballanger B., Broussolle E. Contact dependent reproducible hypomania induced by deep brain stimulation in Parkinson's disease: clinical, anatomical and functional imaging study. J. Neurol. Neurosurg. Psychiatry. 2011;82:607–614. PubMed

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...