Serum autoantibodies against hexokinase 1 manifest secondary to diabetic macular edema onset
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
38821414
DOI
10.1016/j.diabres.2024.111721
PII: S0168-8227(24)00631-4
Knihovny.cz E-zdroje
- Klíčová slova
- Autoimmunity, Disease marker, Disease prediction, Glycolysis, Tissue damage, Vitreous fluid,
- MeSH
- autoprotilátky * krev imunologie MeSH
- biologické markery krev MeSH
- diabetes mellitus 1. typu imunologie komplikace krev MeSH
- diabetes mellitus 2. typu imunologie komplikace krev MeSH
- diabetická retinopatie * imunologie krev MeSH
- dospělí MeSH
- hexokinasa * imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- makulární edém * imunologie krev MeSH
- prospektivní studie MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- autoprotilátky * MeSH
- biologické markery MeSH
- hexokinasa * MeSH
- HK1 protein, human MeSH Prohlížeč
AIMS: Autoantibodies against hexokinase 1 (HK1) were recently proposed to be associated with diabetic macular edema (DME). We hypothesized that anti-HK1 autoantibodies can be used as DME markers and to predict DME onset. MATERIALS AND METHODS: Serum from patients with 1) DME, 2) diabetes mellitus (DM), 3) allergies or autoimmunities, and 4) control subjects was tested for anti-HK1 and anti-hexokinase 2 (HK2) autoantibodies by immunoblotting. Patients with DM were prospectively followed for up to nine years, and the association of anti-HK1 antibodies with new-onset DME was evaluated. The vitreous humor was also tested for autoantibodies. RESULTS: Among patients with DME, 32 % were positive for anti-HK1 autoantibodies (42 % of those with underlying type 1 DM and 31 % of those with underlying type 2 DM), and 12 % were positive for anti-HK2 autoantibodies, with only partial overlap of these two groups of patients. Anti-HK1 positive were also 7 % of patients with DM, 6 % of patients with allergies and autoimmunities, and 3 % of control subjects. The latter three groups were anti-HK2 negative. Only one of seven patients with DM who were initially anti-HK1 positive developed DME. CONCLUSIONS: Anti-HK1 autoantibodies can be used as DME markers but fail to predict DME onset.
3rd Faculty of Medicine Charles University Prague Czech Republic
Department of Ophthalmology University Hospital Hradec Králové Hradec Králové Czech Republic
Department of Ophthalmology University Hospital Ostrava Ostrava Czech Republic
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