Nanotechnology has emerged as a promising solution for tackling antibiotic resistance in monogastric animals, providing innovative methods to enhance animal health and well-being. This review explores the novel use of nanotechnology-based nanomaterials as substitutes for antibiotics in monogastric animals. With growing global concerns about antibiotic resistance and the need for sustainable practices in animal husbandry, nanotechnology offers a compelling avenue to address these challenges. The objectives of this review are to find out the potential of nanomaterials in improving animal health while reducing reliance on conventional antibiotics. We examine various forms of nanomaterials and their roles in promoting gut health and also emphasize fresh perspectives brought by integrating nanotechnology into animal healthcare. Additionally, we delve into the mechanisms underlying the antibacterial properties of nanomaterials and their effectiveness in combating microbial resistance. By shedding light on the transformative role of nanotechnology in animal production systems. This review contributes to our understanding of how nanotechnology can provide safer and more sustainable alternatives to antibiotics.

BioImaging Unit Space Research Centre Michael Atiyah Building University of Leicester Leicester LE1 RH UK

Department of Animal Nutrition and Forage Production Mendel University in Brno Zemedelska 1 CZ 613 00 Brno Czech Republic

Department of Cell Biology School of Life Sciences Central South University Changsha China

Department of Chemistry University of Ha'il Ha'il 81441 Saudi Arabia

Faculty of Pharmacy Gomal University Dera Ismail Khan Khyber Pakhtunkhwa Peshawar Pakistan

Laboratory of Animal Immunology and Biotechnology Department of Animal Morphology Physiology and Genetics Faculty of AgriSciences Mendel University in Brno Zemedelska 1 613 00 Brno Czech Republic

Livestock and Dairy Development Khyber Pakhtunkhwa Peshawar Pakistan

Radiological Sciences Department College of Applied Medical Sciences King Khalid University Abha 61421 Saudi Arabia

School of Biodiversity One Health and Veterinary Medicine University of Glasgow UK

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