The spectrum of cardiorenal and metabolic diseases comprises many disorders, including obesity, type 2 diabetes (T2D), chronic kidney disease (CKD), atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), dyslipidemias, hypertension, and associated comorbidities such as pulmonary diseases and metabolism dysfunction-associated steatotic liver disease and metabolism dysfunction-associated steatohepatitis (MASLD and MASH, respectively, formerly known as nonalcoholic fatty liver disease and nonalcoholic steatohepatitis [NAFLD and NASH]). Because cardiorenal and metabolic diseases share pathophysiologic pathways, two or more are often present in the same individual. Findings from recent outcome trials have demonstrated benefits of various treatments across a range of conditions, suggesting a need for practice recommendations that will guide clinicians to better manage complex conditions involving diabetes, cardiorenal, and/or metabolic (DCRM) diseases. To meet this need, we formed an international volunteer task force comprising leading cardiologists, nephrologists, endocrinologists, and primary care physicians to develop the DCRM 2.0 Practice Recommendations, an updated and expanded revision of a previously published multispecialty consensus on the comprehensive management of persons living with DCRM. The recommendations are presented as 22 separate graphics covering the essentials of management to improve general health, control cardiorenal risk factors, and manage cardiorenal and metabolic comorbidities, leading to improved patient outcomes.

AdventHealth Translational Research Institute Orlando FL USA

David Geffen School of Medicine UCLA Los Angeles CA USA

Department for Prevention and Care of Diabetes Faculty of Medicine Carl Gustav Carus at the Technische Universität TU Dresden Dresden Germany

Department of Cardiology National and Kapodistrian University of Athens Athens Greece

Department of Endocrinology Katholieke Universiteit Leuven Leuven Belgium

Department of Internal Medicine Icahn School of Medicine at Mount Sinai NY New York USA

Department of Medicine Baylor College of Medicine Houston TX USA

Department of Medicine Baylor College of Medicine Texas Heart Institute Houston TX USA

Department of Medicine Duke University Medical Center Durham NC USA

Department of Nephrology University of Helsinki Finnish Institute for Health and Helsinki University HospitalWelfare Folkhälsan Research Center Helsinki Finland; Department of Diabetes Central Clinical School Monash University Melbourne Australia

Department of Precision and Regenerative Medicine and Ionian Area University of Bari Aldo Moro Bari Italy

Division of Cardiology Duke University School of Medicine Durham NC USA

Division of Cardiology Johns Hopkins University School of Medicine Baltimore MD USA

Division of Endocrinology Metabolism and Nutrition Duke University School of Medicine Durham NC USA

Division of Nephrology Department of Medicine Toronto General Hospital University Health Network University of Toronto Toronto Canada

Division of Nephrology Department of Medicine University of Maryland School of Medicine Baltimore MD USA

Donald and Barbara Zucker School of Medicine at Hofstra Northwell Hempstead Advanced Internal Medicine Group PC East Hills NY USA

Emory University Atlanta GA USA

Grunberger Diabetes Institute Bloomfield Hills MI USA; Wayne State University School of Medicine Detroit MI USA; Oakland University William Beaumont School of Medicine Rochester MI USA; Charles University Prague Czech Republic

Hacettepe University Ankara Turkey

Harvard Medical School Boston University School of Medicine Boston MA USA

Harvard Medical School Brigham and Women's Hospital Boston MA USA

Imperial College London London United Kingdom

Interdisciplinary Research Center Health Science Sant'Anna School of Advanced Studies Pisa Italy

Metabolic Institute of America Tarzana CA USA

Mount Sinai Fuster Heart Hospital Icahn School of Medicine at Mount Sinai NY New York USA

Munich Diabetes Research Group e 5 at Helmholtz Centre Munich Germany

Polyclinique d'Aubervilliers Aubervilliers and Paris Nord University Paris France

Saint Luke's Mid America Heart Institute University of Missouri Kansas City Kansas City MO USA

St Michael's Hospital University of Toronto Toronto Canada

The Center for Diabetes and Endocrine Care University of Miami Miller School of Medicine Hollywood FL USA

The Frist Clinic Nashville TN USA

Tulane University Health Sciences Center New Orleans LA USA

Université Paris Cité Institut Universitaire de France AP HP Hôpital Bichat Cardiology Paris France

University of Alabama at Birmingham Birmingham AL USA

University of California at Irvine Irvine CA USA

University of California San Diego School of Medicine La Jolla CA USA

University of Chicago Medicine Chicago IL USA

University of Colorado Anschutz Medical Campus Aurora CO USA

University of Copenhagen Copenhagen Denmark

University of Glasgow Glasgow United Kingdom

University of Helsinki Finnish Institute for Health and Welfare Helsinki Finland

University of Leeds Leeds United Kingdom

University of Leicester Leicester United Kingdom

University of Liverpool Liverpool United Kingdom

University of Mississippi Medical Center Jackson MS USA

University of Texas Health Science Center San Antonio TX USA

Washington University School of Medicine Saint Louis MO USA

Yale University School of Medicine New Haven CT USA

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