Investigating the effects of radiation, T cell depletion, and bone marrow transplantation on murine gut microbiota
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic-ecollection
Typ dokumentu časopisecké články
PubMed
38903788
PubMed Central
PMC11188301
DOI
10.3389/fmicb.2024.1324403
Knihovny.cz E-zdroje
- Klíčová slova
- BM transplantation, HSC, T cell depleted, T cell replete, microbiome and dysbiosis,
- Publikační typ
- časopisecké články MeSH
Microbiome research has gained much attention in recent years as the importance of gut microbiota in regulating host health becomes increasingly evident. However, the impact of radiation on the microbiota in the murine bone marrow transplantation model is still poorly understood. In this paper, we present key findings from our study on how radiation, followed by bone marrow transplantation with or without T cell depletion, impacts the microbiota in the ileum and caecum. Our findings show that radiation has different effects on the microbiota of the two intestinal regions, with the caecum showing increased interindividual variation, suggesting an impaired ability of the host to regulate microbial symbionts, consistent with the Anna Karenina principle. Additionally, we observed changes in the ileum composition, including an increase in bacterial taxa that are important modulators of host health, such as Akkermansia and Faecalibaculum. In contrast, radiation in the caecum was associated with an increased abundance of several common commensal taxa in the gut, including Lachnospiraceae and Bacteroides. Finally, we found that high doses of radiation had more substantial effects on the caecal microbiota of the T-cell-depleted group than that of the non-T-cell-depleted group. Overall, our results contribute to a better understanding of the complex relationship between radiation and the gut microbiota in the context of bone marrow transplantation and highlight the importance of considering different intestinal regions when studying microbiome responses to environmental stressors.
Department of Medical Cell Biology Uppsala University Uppsala Sweden
Department of Zoology Faculty of Science Charles University Prague Czechia
Immunology Programme The Babraham Institute Cambridge United Kingdom
Institute of Vertebrate Biology Czech Academy of Sciences Brno Czechia
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