The work is focused on the degradation, cytotoxicity, and antibacterial properties, of iron-based biomaterials with a bioactive coating layer. The foam and the compact iron samples were coated with a polyethylene glycol (PEG) polymer layer without and with gentamicin sulfate (PEG + Ge). The corrosion properties of coated and uncoated samples were studied using the degradation testing in Hanks' solution at 37 °C. The electrochemical and static immersion corrosion tests revealed that the PEG-coated samples corroded faster than samples with the bioactive PEG + Ge coating and uncoated samples. The foam samples corroded faster compared with the compact samples. To determine the cytotoxicity, cell viability was monitored in the presence of porous foam and compact iron samples. The antibacterial activity of the samples with PEG and PEG + Ge against Escherichia coli CCM 3954 and Staphylococcus aureus CCM 4223 strains was also tested. Tested PEG + Ge samples showed significant antibacterial activity against both bacterial strains. Therefore, the biodegradable iron-based materials with a bioactive coating could be a suitable successor to the metal materials studied thus far as well as the materials used in the field of medicine.

Centre of Polymer Systems University Institute Tomáš Bat'a University in Zlín Třida Tomáše Bati 5678 76001 Zlín Czech Republic

Department of Microbiology and Immunology University of Veterinary Medicine and Pharmacy in Košice Komenského 73 041 81 Košice Slovakia

Department of Physical Chemistry P J Šafárik University in Košice Moyzesova 11 041 01 Košice Slovakia

Institute of Geotechnics Slovak Academy of Sciences Watsonova 45 040 01 Košice Slovakia

Institute of Materials Research Slovak Academy of Sciences Watsonova 47 040 01 Košice Slovakia

Institute of Polymers Slovak Academy of Sciences Dúbravská cesta 9 845 41 Bratislava Slovakia

Small Animal Clinic The University of Veterinary Medicine and Pharmacy in Košice 040 01 Košice Slovakia

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