Aspartate in tumor microenvironment and beyond: Metabolic interactions and therapeutic perspectives
Language English Country Netherlands Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
39111633
DOI
10.1016/j.bbadis.2024.167451
PII: S0925-4439(24)00444-7
Knihovny.cz E-resources
- Keywords
- Amino acid, Biosynthesis, Cancer, Leukemia, Malate-aspartate shuttle, Respiratory chain, Tumor microenvironment,
- MeSH
- Aspartic Acid * metabolism MeSH
- Humans MeSH
- Tumor Microenvironment * MeSH
- Neoplasms * metabolism pathology MeSH
- Cell Proliferation MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Aspartic Acid * MeSH
Aspartate is a proteinogenic non-essential amino acid with several essential functions in proliferating cells. It is mostly produced in a cell autonomous manner from oxalacetate via glutamate oxalacetate transaminases 1 or 2 (GOT1 or GOT2), but in some cases it can also be salvaged from the microenvironment via transporters such as SLC1A3 or by macropinocytosis. In this review we provide an overview of biosynthetic pathways that produce aspartate endogenously during proliferation. We discuss conditions that favor aspartate uptake as well as possible sources of exogenous aspartate in the microenvironment of tumors and bone marrow, where most available data have been generated. We highlight metabolic fates of aspartate, its various functions, and possible approaches to target aspartate metabolism for cancer therapy.
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