Orchestra of ligand-activated transcription factors in the molecular symphony of SERPINE 1 / PAI-1 gene regulation
Language English Country France Media print-electronic
Document type Journal Article, Review
PubMed
39321911
DOI
10.1016/j.biochi.2024.09.010
PII: S0300-9084(24)00220-7
Knihovny.cz E-resources
- Keywords
- AhR, Aryl hydrocarbon receptor, ER, Estrogen receptor, GR, Glucocorticoid receptor, MR, Mineralocorticoid receptor, PR, PXR, Pregnane X receptor, Progesterone receptor, THR, Thyroid hormone receptor, VDR, Vitamin D receptor,
- MeSH
- Plasminogen Activator Inhibitor 1 * metabolism genetics MeSH
- Humans MeSH
- Ligands MeSH
- Gene Expression Regulation * MeSH
- Transcription Factors metabolism genetics MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Plasminogen Activator Inhibitor 1 * MeSH
- Ligands MeSH
- SERPINE1 protein, human MeSH Browser
- Transcription Factors MeSH
Plasminogen activator inhibitor 1 (PAI-1) is a crucial serine protease inhibitor that prevents plasminogen activation by inhibiting tissue- and urokinase-type plasminogen activators (tPA, uPA). PAI-1 is well-known for its role in modulating hemocoagulation or extracellular matrix formation by inhibiting plasmin or matrix metalloproteinases, respectively. PAI-1 is induced by pro-inflammatory cytokines across various tissues, yet its regulation by ligand-activated transcription factors is partly disregarded. Therefore, we have attempted to summarize the current knowledge on the transcriptional regulation of PAI-1 expression by the most relevant xenobiotic and endocrine receptors implicated in modulating PAI-1 levels. This review aims to contribute to the understanding of the specific, often tissue-dependent regulation of PAI-1 and provide insights into the modulation of PAI-1 levels beyond its direct inhibition.
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