The marine environment is considered one of the most important ecosystems with high biodiversity. Microorganisms in this environment are variable and coexist with other marine organisms. The microbes associated with other marine organisms produce compounds with biological activity that may help the host's defense against invading organisms. The symbiotic association of bacteria with marine invertebrates is of ecological and biotechnological importance. Biologically active metabolites isolated from bacteria associated with marine invertebrates are considered potential sources of natural antimicrobial molecules for treating infectious diseases. Many studies have been conducted to screen the antimicrobial activity of metabolites produced by bacteria associated with marine invertebrates. This work provides an overview of the advancements in antimicrobial compound research on bacteria associated with marine invertebrates.

Department of Aquaculture Faculty of Fisheries and Marine Universitas Airlangga 60115 Surabaya Indonesia

Department of Biology Faculty of Sciences King Abdulaziz University Jeddah Saudi Arabia

Department of Marine Biology and Fisheries Faculty of Marine Science and Environments Hodeidah University P O Box 3114 Hodeidah Yemen

Department of Marine Biology Faculty of Marine Sciences King Abdulaziz University P O Box 80207 21589 Jeddah Saudi Arabia

Marine Natural Products Research Unit King Fahad Medical Research Centre King Abdulaziz University Jeddah Saudi Arabia

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