Poly(2-(N,N-dimethylamino)ethyl acrylate) (PDMAEA) is a promising charge-shifting polycation with the capacity to form a range of morphologically distinct polyelectrolyte assemblies. Nevertheless, the basic character of the monomer and its hydrolytic instability impedes its controlled synthesis to higher molecular weight (MW). Herein, the reversible addition-fragmentation chain transfer polymerization of DMAEA is reported using a tert-butanol/V70 initiator/trithiocarbonate-based chain transfer agent (CTA) polymerization setup. The CTA instability is demonstrated in the presence of the unprotonated tertiary amino group of the DMAEA monomer, which limits the control over the conversion and MW of the polymer. In contrast, the shielding of the amino groups by their protonation leads to polymerization with high conversions and excellent control over MWs of polymer up to 100 000 g mol-1. Hydrolytic degradation study at pH values ranging from 5 to 9 reveals that both basic and protonated PDMAEA undergo a pH-dependent hydrolysis. The proposed polymerization conditions provide a means of synthesizing PDMAEA with well-controlled characteristics, which are beneficial for controlling the complexation processes during the formation of various polyelectrolyte assemblies.

Analytical Chemistry Laboratory Institute of Macromolecular Chemistry Czech Academy of Sciences Heyrovsky sq 2 Prague 6 Prague 162 06 Czech Republic

Department of Biomedical Polymers Institute of Macromolecular Chemistry Czech Academy of Sciences Heyrovsky sq 2 Prague 6 Prague 162 06 Czech Republic

Department of Chemistry and Physics of Surfaces and Biointerfaces Institute of Macromolecular Chemistry Czech Academy of Sciences Heyrovsky sq 2 Prague 6 Prague 162 06 Czech Republic

Department of Polymer and Colloid Immunotherapeutics Institute of Macromolecular Chemistry Czech Academy of Sciences Heyrovsky sq 2 Prague 6 Prague 162 06 Czech Republic

Department of Structural Analysis Institute of Macromolecular Chemistry Czech Academy of Sciences Heyrovsky sq 2 Prague 6 Prague 162 06 Czech Republic

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