Oscillometry-defined small airways dysfunction as a treatable trait in asthma
Language English Country United States Media print-electronic
Document type Journal Article, Review
PubMed
39549987
DOI
10.1016/j.anai.2024.11.006
PII: S1081-1206(24)01658-2
Knihovny.cz E-resources
- MeSH
- Anti-Asthmatic Agents therapeutic use MeSH
- Asthma * physiopathology drug therapy diagnosis MeSH
- Adrenal Cortex Hormones therapeutic use MeSH
- Humans MeSH
- Oscillometry * methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Anti-Asthmatic Agents MeSH
- Adrenal Cortex Hormones MeSH
The small airways, also referred to as the lung's silent zone, are closely associated with poor symptom control and more frequent asthma exacerbations. The oscillometry technique superimposes sound or airwaves onto normal tidal breathing and provides information on resistance and reactance, that is, obstacles to airflow occurring inside and outside of the bronchi. More recently, a management paradigm based on so-called "treatable traits" has been proposed to personalize and improve asthma care for individuals by proactively identifying and targeting modifiable pulmonary, extrapulmonary, and behavioral traits affecting asthma control. In this review article, we evaluate the literature on small airways dysfunction as a potential treatable trait in persistent asthma. In particular, we discuss whole- and intrabreath oscillometry and the impact of extrafine inhaled corticosteroids and systemic biologics on the peripheral airways.
Allergy and Pneumology Outpatient Clinic Bergamo Italy
Department of Cellular Computational and Integrative Biology University of Trento Trento Italy
Pulmonology Unit S Valentino Hospital Montebelluna Marca Trevigiana Italy
University of Dundee School of Medicine Dundee United Kingdom
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