Regenerative Potential of PDL-Derived Small Extracellular Vesicles
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
Czech Science Foundation, project GACR 21-21409S
NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London
PubMed
39581762
PubMed Central
PMC12139699
DOI
10.1111/jre.13356
Knihovny.cz E-zdroje
- MeSH
- buněčná diferenciace MeSH
- extracelulární vezikuly * fyziologie MeSH
- fibroblasty fyziologie MeSH
- gingiva cytologie MeSH
- hojení ran fyziologie MeSH
- lidé MeSH
- osteogeneze fyziologie MeSH
- periodontální vaz * cytologie fyziologie MeSH
- regenerace * fyziologie MeSH
- signální dráha Wnt fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Treatment of gingival fibroblasts with PDL extracellular vesicles results in promotion of Wnt signalling pathway and osteogenic differentiation. PDL secretome shows selective wound healing and matrix remodelling which can have implications for future periodontal regenerative strategies.
Centre of Excellence for Mass Spectrometry Denmark Hill King's College London London UK
Institute of Animal Physiology and Genetics Czech Academy of Sciences Brno Czech Republic
Zobrazit více v PubMed
Fonticoli L., Della Rocca Y., Rajan T. S., et al., “A Narrative Review: Gingival Stem Cells as a Limitless Reservoir for Regenerative Medicine,” International Journal of Molecular Sciences 23 (2022): 4135. PubMed PMC
Jarrige M., Frank E., Herardot E., et al., “The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles,” Cells 10 (2021): 240. PubMed PMC
Garna D. F., Hughes F. J., and Ghuman M. S., “Regulation of Gingival Fibroblast Phenotype by Periodontal Ligament Cells In Vitro,” Journal of Periodontal Research 57 (2022): 402–411. PubMed PMC
Hua S., Bartold P. M., Gulati K., Moran C. S., Ivanovski S., and Han P., “Periodontal and Dental Pulp Cell‐Derived Small Extracellular Vesicles: A Review of the Current Status,” Nanomaterials 11 (2021): 1858. PubMed PMC
Olaechea A., Benabdellah K., Vergara‐Buenaventura A., et al., “Preclinical Evidence for the Use of Oral Mesenchymal Stem Cell‐Derived Extracellular Vesicles in Bone Regenerative Therapy: A Systematic Review,” Stem Cells Translational Medicine 12 (2023): 791–800. PubMed PMC
Han P., Johnson N., Abdal‐hay A., Moran C. S., Salomon C., and Ivanovski S., “Effects of Periodontal Cells‐Derived Extracellular Vesicles on Mesenchymal Stromal Cell Function,” Journal of Periodontal Research 58 (2023): 1188–1200. PubMed
Lan Q., Xiao X., Bi X., Gu Y., and Ai Y., “Effects of Periodontal Ligament Stem Cell‐Derived Exosomes on Osteoblastic Proliferation, Migration, Differentiation, Apoptosis, and Signaling Pathways,” Oral Diseases 30 (2022): 710–718, 10.1111/odi.14375. PubMed DOI
Patten J. and Wang K., “Fibronectin in Development and Wound Healing,” Advanced Drug Delivery Reviews 170 (2021): 353–368. PubMed
Guru S. R. and Aghanashini S., “Impact of Scaling and Root Planing on Salivary and Serum Plasminogen Activator Inhibitor‐1 Expression in Patients With Periodontitis With and Without Type 2 Diabetes Mellitus,” Journal of Periodontology 94 (2023): 20–30. PubMed
Glim J. E., Everts V., Niessen F. B., Ulrich M. M., and Beelen R. H. J., “Extracellular Matrix Components of Oral Mucosa Differ From Skin and Resemble That of Foetal Skin,” Archives of Oral Biology 59 (2014): 1048–1055. PubMed
