Background/Objectives: Acute appendicitis (AA) is one of the most common causes of emergency department visits due to acute abdominal pain, with a lifetime risk of 7-8%. Managing AA presents significant challenges, particularly among vulnerable patient groups, due to its association with substantial morbidity and mortality. Methods: The EUPEMEN (European PErioperative MEdical Networking) project aims to optimize perioperative care for AA by developing multidisciplinary guidelines that integrate theoretical knowledge and clinical expertise from five European countries. This study presents the key elements of the EUPEMEN protocol, which focuses on reducing surgical stress, optimizing perioperative care, and enhancing postoperative recovery. Results: Through this standardized approach, the protocol aims to lower postoperative morbidity and mortality, shorten hospital stays, and improve overall patient outcomes. The recommendations are tailored to address the variability in clinical practice across Europe and are designed to be widely implementable in diverse healthcare settings. Conclusions: The conclusions drawn from this study highlight the potential for the EUPEMEN protocol to significantly improve perioperative care standards for AA, demonstrating its value as a practical, adaptable tool for clinicians.

4th Department of Surgery Medical School Faculty of Health Sciences Aristotle University of Thessaloniki General Hospital George Papanikolaou 57010 Thessaloniki Greece

Department of Anesthesia Resuscitation and Pain Therapy Miguel Servet University Hospital 50009 Zaragoza Spain

Department of Plastic Surgery 2nd Faculty of Medicine Charles University and Motol University Hospital 150 06 Prague Czech Republic

Department of Surgery 2nd Faculty of Medicine Charles University and Motol University Hospital 150 06 Prague Czech Republic

Department of Surgery Azienda Unità Sanitaria Locale Ferrara University of Ferrara 44121 Ferrara Italy

Department of Surgery Faculty of Medicine University of Zaragoza 50009 Zaragoza Spain

Department of Surgery Universidad Miguel Hernández Elche Hospital General Universitario Elche 03203 Elche Spain

Department of Surgery University Hospital Kralovske Vinohrady 100 34 Prague Czech Republic

Grupo Español de Rehabilitación Multimodal 50009 Zaragoza Spain

Institute for Health Research Aragón 50009 Zaragoza Spain

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Improving Perioperative Care in Gastric Surgery: Insights from the EUropean PErioperative MEdical Networking (EUPEMEN) Project