Long non-coding RNAs (lncRNAs) play vital roles in the development and progression of various tumors through multiple mechanisms. Among these, HOTTIP (HOXA transcript at the distal tip) stands out as an intriguing candidate with diverse functions in several malignancies, including breast cancer and gynecologic cancers such as ovarian, cervical, and endometrial cancers, which are significant global health concerns. HOTTIP interacts with key signaling pathways associated with these cancers, including Wnt/β-catenin, PI3K/AKT, and MEK/ERK pathways, enhancing their activation and downstream effects. Its influence extends to crucial aspects of cancer biology, such as cell proliferation, apoptosis, migration, invasion, angiogenesis, and epithelial-mesenchymal transition (EMT). Additionally, HOTTIP plays a pivotal role in the pathogenesis of breast and gynecologic tumors by sponging various microRNAs (miRNAs) and regulating the expression of mRNAs involved in critical molecular processes. This dysregulation is often associated with poor clinical outcomes, advanced disease stages, and distant metastases. Understanding the functional roles of HOTTIP in these cancers is essential for developing targeted therapeutic strategies. This review aims to explore the emerging roles of HOTTIP in breast and gynecologic cancers.

Cancer Environmental and Petroleum Pollutants Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Cellular and Molecular Research Center Medical Basic Sciences Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Center of Assisted Reproduction Department of Obstetrics and Gynecology University Hospital and Masaryk University Brno Czech Republic

Chronic Renal Failure Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Clinical Research Development Unit Imam Khomeini Hospital Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Department of Human Morphology and Embryology Division of Anatomy Wrocław Medical University Poland

Department of Laboratory Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran

Department of Obstetrics and Gynecology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Department of Veterinary Surgery Institute of Veterinary Medicine Nicolaus Copernicus University Torun Poland

Fertility Infertility and Perinatology Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Physiology Graduate Faculty North Carolina State University Raleigh NC 27695 US

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