This review provides a comprehensive update on the diagnostic approaches to chronic pancreatitis (CP), emphasizing recent advancements in imaging techniques, biomarker research, and multivariable scoring systems. Despite substantial progress in these areas, current diagnostic algorithms have limitations, particularly for early and non-calcific CP. Traditional criteria have focused on classic diagnostic signs, but "minimal change" CP is increasingly recognized through advanced imaging and function tests. This article aims to guide clinicians in applying current methods and available strategies for CP diagnosis and outline research efforts in the field.

Division of Gastroenterology Hepatology and Nutrition University of Minnesota 420 Delaware Street Southeast Minneapolis MN 55455 USA

Faculty of Medicine and Dentistry Palacky University Olomouc Hnevotinska 3 77900 Olomouc Czech Republic; Department of Gastroenterology and Digestive Endoscopy Masaryk Memorial Cancer Institute Zluty Kopec 7 65653 Brno Czech Republic

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