Spray drying and hot-melt extrusion are among the most prevalent preparation techniques used in the pharmaceutical industry to produce amorphous solid dispersions (ASDs). This study advances previous research by integrating sample production, comprehensive analytical characterization, intrinsic dissolution rate measurements, and assessments of the behavior of ASDs under elevated temperature and humidity conditions. The study focuses on indomethacin, a widely used model for poorly soluble drugs, processed with PVP K30 or HPMC E5, both commonly used polymers. The findings demonstrate that hot-melt extruded samples exhibit superior stability against recrystallization, whereas spray dried samples achieve higher intrinsic dissolution rates. Furthermore, PVP K30 significantly outperforms HPMC E5 in the co-processing of indomethacin, enhancing both the intrinsic dissolution rate and the stability.

Department of Chemical Engineering University of Chemistry and Technology Prague Technická 5 166 28 Prague 6 Dejvice Czech Republic

Department of Chemical Engineering University of Chemistry and Technology Prague Technická 5 166 28 Prague 6 Dejvice Czech Republic; Zentiva k s Ukabelovny 130 10237 Prague 10 Czech Republic

Division of Pharmaceutical Chemistry and Technology University of Helsinki Viikinkaari 5 E 00014 Helsinki Finland; Helsinki Institute of Sustainability Science HELSUS Finland

Zentiva k s Ukabelovny 130 10237 Prague 10 Czech Republic

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