Childhood epilepsy is frequently associated with neurobehavioral comorbidities such as depression, anxiety, cognitive impairments, and social dysfunction, as revealed by both clinical and experimental studies. Despite extensive neurophysiological research, behavioral studies in developing animals remain limited and underreported. Here, we review the behavioral impact of early-life seizures (ELSs) in commonly used rat models in developmental studies. We outline suitable tests and provide guidance on how traditional tests should be adapted and interpreted in this context. Finally, we examine factors influencing behavioral analysis in developmental studies, exploring confounding variables and offering strategies to minimize their impact.

Developmental Epileptology Institute of Physiology of the Czech Academy of Science Prague Czech Republic

Developmental Epileptology Institute of Physiology of the Czech Academy of Science Prague Czech Republic; Department of Physiology Faculty of Science Charles University Prague Czech Republic

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