Total psoriasis regression in a patient with chronic myeloid leukemia treated using nilotinib
Language English Country Germany Media print-electronic
Document type Case Reports, Journal Article
PubMed
40016401
PubMed Central
PMC12031779
DOI
10.1007/s00277-025-06228-x
PII: 10.1007/s00277-025-06228-x
Knihovny.cz E-resources
- Keywords
- Adverse effects, Chronic myeloid leukemia, Nilotinib, Psoriasis, Tyrosine kinase inhibitors,
- MeSH
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive * drug therapy complications MeSH
- Protein Kinase Inhibitors * therapeutic use adverse effects administration & dosage MeSH
- Humans MeSH
- Psoriasis * drug therapy complications chemically induced pathology MeSH
- Pyrimidines * therapeutic use adverse effects administration & dosage MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Protein Kinase Inhibitors * MeSH
- nilotinib MeSH Browser
- Pyrimidines * MeSH
Chronic myeloid leukemia (CML) treatment has been revolutionized over last 20 years because of tyrosine kinase inhibitors (TKIs) and patients with CML now have life expectancy of general population. Chronic TKI treatment may cause adverse effects (AEs) that vary in frequency and severity. Nilotinib shows common AEs with metabolic changes and skin AEs. Here, we present a case report of patient who experienced full psoriasis regression while treated with nilotinib. Dose reductions and an attempt to stop nilotinib treatment resulted in prompt psoriasis reappearance. This is the first documented case of positive effect of nilotinib on psoriasis.
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