Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
40068682
DOI
10.1016/j.cell.2025.02.011
PII: S0092-8674(25)00196-5
Knihovny.cz E-zdroje
- Klíčová slova
- brassinosteroids, cell cycle, cell division, cell polarity, live-cell imaging, root meristem, single-cell RNA sequencing,
- MeSH
- Arabidopsis * metabolismus cytologie růst a vývoj MeSH
- brassinosteroidy * metabolismus MeSH
- kořeny rostlin * cytologie metabolismus růst a vývoj MeSH
- meristém metabolismus cytologie MeSH
- mitóza * MeSH
- polarita buněk * MeSH
- proliferace buněk MeSH
- proteiny huseníčku metabolismus genetika MeSH
- regulace genové exprese u rostlin MeSH
- regulátory růstu rostlin metabolismus MeSH
- signální transdukce MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- brassinosteroidy * MeSH
- proteiny huseníčku MeSH
- regulátory růstu rostlin MeSH
Brassinosteroid hormones are positive regulators of plant organ growth, yet their function in proliferating tissues remains unclear. Here, through integrating single-cell RNA sequencing with long-term live-cell imaging of the Arabidopsis root, we reveal that brassinosteroid activity fluctuates throughout the cell cycle, decreasing during mitotic divisions and increasing during the G1 phase. The post-mitotic recovery of brassinosteroid activity is driven by the intrinsic polarity of the mother cell, resulting in one daughter cell with enhanced brassinosteroid signaling, while the other supports brassinosteroid biosynthesis. The coexistence of these distinct daughter cell states during the G1 phase circumvents a negative feedback loop to facilitate brassinosteroid production while signaling increases. Our findings uncover polarity-guided, uneven mitotic divisions in the meristem, which control brassinosteroid hormone activity to ensure optimal root growth.
Centro de Biotecnología y Genómica de Plantas Madrid 28040 Spain
Department of Biology Duke University Durham NC USA
Faculty of Biology Technion Israel Institute of Technology Haifa 3200003 Israel
Institute of Molecular Plant Biology Department of Biology ETH Zurich Zurich 8092 Switzerland
Laboratoire de Biogenèse Membranaire UMR5200 CNRS Université de Bordeaux Villenave d'Ornon France
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