Pharmacokinetics of the systemic application of hyaluronic acid for joint arthritis treatment
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
40074120
DOI
10.1016/j.ijbiomac.2025.141937
PII: S0141-8130(25)02488-2
Knihovny.cz E-zdroje
- Klíčová slova
- Hyaluronan, Inflammation, Intraperitoneal, Intravenous, Pharmacokinetics, Rheumatoid arthritis, Stable isotope, Vascular leakage,
- MeSH
- artritida experimentální * chemicky indukované farmakoterapie metabolismus MeSH
- injekce intraartikulární MeSH
- injekce intravenózní MeSH
- klouby * účinky léků patologie MeSH
- kyselina hyaluronová * aplikace a dávkování farmakokinetika MeSH
- modely nemocí na zvířatech MeSH
- myši MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kyselina hyaluronová * MeSH
Frequent degenerative joint diseases, known as arthritis, are characterized by joint inflammation and cartilage breakdown. Various arthritis types are traditionally managed with intraarticular injections of hyaluronan or its derivatives. However, intravenous administration of hyaluronan is emerging as a vital alternative, particularly because intraarticular injections can be challenging for clinicians when targeting small or swollen joints. Pharmacokinetics of intravenously and intraperitoneally administered middle-Mw hyaluronan were studied in an adjuvant-induced arthritis mouse model alongside therapeutic effects. Using 13C-, biotin- and fluoresce-labeling, we found hyaluronan accumulated in inflamed joint tissues while distribution in other organs remained similar to healthy controls. Repeated administrations significantly reduced arthritis symptoms like swelling and redness, RANKL, inducible nitric oxide synthase, COMP and prostaglandin E2 levels. Moreover, hyaluronan treatment prevented dextran-FITC penetration into inflamed paws suggesting reduced vascular permeability at the site of inflammation. These findings support systemic hyaluronan administration as a promising arthritis treatment strategy.
Contipro a s Dolní Dobrouč Czech Republic
Institute of Biophysics of the Czech Academy of Sciences Brno Czech Republic
Citace poskytuje Crossref.org
