Respiratory viruses represent a significant public health threat. There is the need for robust and coordinated surveillance to guide global health responses. Established in 2012, the Global Influenza Hospital Surveillance Network (GIHSN) addresses this need by collecting clinical and virological data on persons with acute respiratory illnesses across a network of hospitals worldwide. GIHSN utilizes a standardized patient enrolment and data collection protocol across its study sites. It leverages pre-existing national infrastructures and expert collaborations to facilitate comprehensive data collection. This includes demographic, clinical, epidemiological, and virologic data, and whole genome sequencing (WGS) for a subset of viruses. Sequencing data are shared in the Global Initiative on Sharing All Influenza Data (GISAID). GIHSN uses financing and governance approaches centered around public-private partnerships. Over time, GIHSN has included more than 100 hospitals across 27 countries and enrolled more than 168,000 hospitalized patients, identifying 27,562 cases of influenza and 44,629 of other respiratory viruses. GIHSN has expanded beyond influenza to include other respiratory viruses, particularly since the COVID-19 pandemic. In November 2023, GIHSN strengthened its global impact through a memorandum of understanding with the World Health Organization, aimed at enhancing collaborative efforts and data sharing for improved health responses. GIHSN exemplifies the value of integrating scientific research with public health initiatives through global collaboration and public-private partnerships governance. Future efforts should enhance the scalability of such models and ensure their sustainability through continued public and private support.

AP HP CIC Vaccinologie Cochin Pasteur Hospital Cochin Paris France

Center for Infectious Diseases Research American University of Beirut Beirut Lebanon

Center for Vaccine Development and Global Health University of Maryland School of Medicine Baltimore Maryland USA

Center of Excellence in Respiratory Pathogens Lyon France

Clínica Internacional Instituto de Medicina Tropical Universidad Nacional Mayor de San Marcos Lima Peru

Dalhousie University Halifax Canada

Davila University of Medicine and Pharmacy Bucharest Romania

Department of Epidemiology Faculty of Medicine University of Novi Sad Novi Sad Serbia

Department of Infectious Diseases and Clinical Microbiology Hacettepe University School of Medicine Ankara Türkiye

Division of International Epidemiology and Population Studies Fogarty International Center National Institutes of Health Bethesda Maryland USA

Epidemiology Immunization and Infection Control Department Hospital Pequeno Principe Curitiba Brazil

FISABIO Public Health Valencia Spain

Foundation for Influenza Epidemiology Fondation de France Paris France

Gamaleya National Research Center for Epidemiology and Microbiology Ministry of Health of Russian Federation Moscow Russia

Global Influenza Program WHO Geneva Switzerland

Grupo de Investigación UNIMOL Facultad de Medicina Universidad de Cartagena Cartagena de Indias Colombia

HCL and CIRI Épidémiologie et Écologie Évolutive des Maladies Infectieuses Inserm U1111 CNRS UMR5308 ENS de Lyon UCBL Lyon 1 Lyon France

HCL and CIRI Inserm U1111 CNRS UMR5308 ENS de Lyon UCBL Lyon 1 Lyon France

HCL Lyon France

Icahn School of Medicine at Mount Sinai New York New York USA

Impact Healthcare Paris France

Institut National d'Hygiène Publique Abidjan Côte d'Ivoire

Institut Pasteur de Tunis Tunis Tunisia

Institut Pasteur of Dakar Dakar Senegal

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City Mexico

Kenya Medical Research Institute Nairobi Kenya

Medical University of Warsaw Warsaw Poland

Molecular Biology Microbiology Research Laboratory Universidade Federal do Paraná Curitiba Brazil

National Institute for Infectious Diseases Prof Dr Matei Bals Bucharest Romania

National Institute of Health lslamadad Pakistan

National Institute of Public Health Prague Czech Republic

National Reference Laboratory for Viral Respiratory Diseases Virology Department INEI ANLIS Buenos Aires Argentina

Partnership for International Vaccine Initiatives The Task Force for Global Health Decatur Georgia USA

Patan Academy of Health Sciences Patan Nepal

School of Public Health Fudan University Shanghai China

School of Public Health University of Hong Kong Hong Kong China

Sher i Kashmir Institute Srinagar India

SI Kyiv City Center for Diseases Control and Prevention of the Ministry of Health of Ukraine Kyiv Ukraine

Smorodintsev Research Institute of Influenza Saint Petersburg Russia

South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa

The CIRN Serious Outcomes Surveillance Network Halifax Canada

Université Paris Cité Assistance Publique Hôpitaux de Paris CIC Vaccinologie Cochin Pasteur Hôpital Cochin Inserm FCRIN 1 REIVAC Paris France

Vaccine Institute Hacettepe University Ankara Türkiye

Worldwide Influenza Centre The Francis Crick Institute London UK

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