Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
40118050
DOI
10.1016/j.ccell.2025.03.002
PII: S1535-6108(25)00081-9
Knihovny.cz E-resources
- MeSH
- Clinical Relevance MeSH
- Humans MeSH
- DNA, Mitochondrial genetics MeSH
- Mitochondria * genetics metabolism MeSH
- Neoplasms * genetics pathology metabolism MeSH
- Gene Transfer, Horizontal * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- DNA, Mitochondrial MeSH
Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.
Institute of Biotechnology Czech Academy of Sciences Prague West 252 50 Czech Republic
Malaghan Institute of Medical Research Wellington 6242 New Zealand
Norwich Medical School University of East Anglia Norwich NR4 7UQ UK
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