Respiratory syncytial virus prefusion F3 vaccine in lung transplant recipients elicits CD4+ T cell response in all vaccinees
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
40169094
DOI
10.1016/j.ajt.2025.03.025
PII: S1600-6135(25)00164-9
Knihovny.cz E-resources
- Keywords
- RSV vaccine, T cell response, antibody response, immunogenicity, lung transplantation, respiratory syncytial virus,
- MeSH
- Immunity, Cellular MeSH
- CD4-Positive T-Lymphocytes * immunology MeSH
- Respiratory Syncytial Virus Infections * prevention & control immunology virology MeSH
- Middle Aged MeSH
- Humans MeSH
- Respiratory Syncytial Virus, Human * immunology MeSH
- Follow-Up Studies MeSH
- Transplant Recipients MeSH
- Prognosis MeSH
- Antibodies, Viral immunology blood MeSH
- Respiratory Syncytial Viruses * immunology MeSH
- Aged MeSH
- Lung Transplantation * adverse effects MeSH
- Respiratory Syncytial Virus Vaccines * immunology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antibodies, Viral MeSH
- Respiratory Syncytial Virus Vaccines * MeSH
Respiratory syncytial virus (RSV) causes seasonal acute respiratory illness significantly impacting vulnerable groups, including lung transplant recipients, who are at increased risk of hospitalization, acute rejection, and allograft dysfunction. The immunogenicity of the novel RSV prefusion F3 (RSVPreF3-AS01, Arexvy, GlaxoSmithKline) vaccine in immunocompromised patients remains largely unknown. In this study, we assessed both antibody-using and cellular immune responses 2 months after a single dose of the RSVPreF3-AS01 vaccine in 30 lung transplant recipients aged 60 years or older, who were at least 6 months posttransplant. The antibody response was assessed using enzyme-linked immunosorbent assay for detection of serum anti-RSV-F IgG specific antibodies, and the CD4+ T cell response was measured by flow cytometry intracellular cytokine secretion assay. Our findings show that all vaccinees exhibited a CD4+ T cell response 2 months postvaccination, whereas only 40% demonstrated an antibody response. These results suggest that some patients may derive clinical benefit from the vaccine through cellular immunity, even without an antibody response. Furthermore, the vaccine was well tolerated in this vulnerable population, with no major safety concerns observed.
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