Successful limb-salvage procedure using a bioexpandable prosthesis after infected primary reconstruction of the distal femur in a skeletally immature patient: a case report
Jazyk angličtina Země Anglie, Velká Británie Médium electronic
Typ dokumentu časopisecké články, kazuistiky
PubMed
40176042
PubMed Central
PMC11963633
DOI
10.1186/s12957-025-03759-5
PII: 10.1186/s12957-025-03759-5
Knihovny.cz E-zdroje
- Klíčová slova
- Bioexpandable prosthesis, Knee revision, Lengthening nail, Limb-salvage surgery, MUTARS® BioXpand, Periprosthetic infection, Precise nail,
- MeSH
- femur * chirurgie patologie MeSH
- infekce spojené s protézou * chirurgie etiologie MeSH
- lidé MeSH
- mladiství MeSH
- nádory femuru * chirurgie patologie MeSH
- nádory kostí * chirurgie patologie MeSH
- osteosarkom * chirurgie patologie MeSH
- prognóza MeSH
- reoperace MeSH
- záchrana končetiny * metody MeSH
- zákroky plastické chirurgie * metody MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
BACKGROUND: Periprosthetic infections pose a devastating complication in skeletally immature patients treated for an orthopaedic oncological condition. Reconstructive approaches to revision procedures are often limited, and many cases still require amputation. CASE PRESENTATION: In this report, we present our unique experience with the bio-expandable MUTARS® BioXpand prosthesis, utilized during the second stage of a revision surgery in an adolescent female patient. Initially, the patient underwent reconstruction using a conventional endoprosthesis following the resection of a high-grade distal femur osteosarcoma; however, she developed a deep infection six months later. During a two-stage revision procedure, the infection was successfully eradicated at the cost of loss of growth potential at also the site of proximal tibia. The initial 5 cm limb-length discrepancy was restored through the application of bioexpandable endoprosthesis, which allowed for an 8 cm gain in bone stock. At the last follow-up appointment, the patient was fully weight-bearing and demonstrated excellent clinical outcomes, with no evidence of infection or tumor recurrence. CONCLUSION: This successful limb-salvage procedure indicates that bioexpandable endoprosthesis may serve as a viable and effective reconstructive option in revision surgery for skeletally immature individuals.
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Coathup MJ, Ahmad S, Maempel JF, Briggs TW, Aston WJ, Skinner JA, Blunn GW. Non-invasive massive growing prostheses reduce infection in paediatric cancer patients. J Orthop Surg (Hong Kong). 2019;27(1):2309499019833403. 10.1177/2309499019833403. PubMed
Gonzalez MR, Pretell-Mazzini J, Lozano-Calderon SA. Risk factors and management of prosthetic joint infections in megaprostheses—a review of the literature. Antibiot (Basel). 2023;13(1):25. 10.3390/antibiotics13010025. PubMed PMC
Jeys LM, Grimer RJ, Carter SR, Tillman RM. Periprosthetic infection in patients treated for an orthopaedic oncological condition. J Bone Joint Surg Am. 2005;87(4):842–9. 10.2106/JBJS.C.01222. PubMed
Lex JR, Adlan A, Tsoi K, Evans S, Stevenson JD. Frequency and reason for reoperation following non-invasive expandable endoprostheses: a systematic review. J Bone Oncol. 2021;31:100397. 10.1016/j.jbo.2021.100397. PubMed PMC
Morii T, Morioka H, Ueda T, Araki N, Hashimoto N, Kawai A, et al. Deep infection in tumor endoprosthesis around the knee: a multi-institutional study by the Japanese musculoskeletal oncology group. BMC Musculoskelet Disord. 2013;14:51. 10.1186/1471-2474-14-51. PubMed PMC
Pala E, Trovarelli G, Angelini A, Maraldi M, Berizzi A, Ruggieri P. Megaprosthesis of the knee in tumor and revision surgery. Acta Biomed. 2017;88(2S):129–38. 10.23750/abm.v88i2-S.6523. PubMed PMC
Theil C, Röder J, Gosheger G, Deventer N, Dieckmann R, Schorn D, et al. What is the likelihood that tumor endoprostheses will experience a second complication after first revision in patients with primary malignant bone tumors and what are potential risk factors? Clin Orthop Relat Res. 2019;477(12):2705–14. 10.1097/CORR.0000000000000955. PubMed PMC
Včelák J, Matějovský Z Jr, Kofránek I, Kubeš R, Lesenský J. Periprosthetic infection of the knee megaprosthesis following a resection of malignant tumours around the knee. Acta Chir Orthop Traumatol Cech. 2017;84(1):46–51. PubMed
Mavrogenis AF, Papagelopoulos PJ, Coll-Mesa L, Pala E, Colangeli M, Manfrini M, et al. Expandable tumor prostheses in children. J BUON. 2012;17(1):9–15. PubMed
Lenze U, Baumgart R. Einsatz der kallusdistraktion Zur rekonstruktion Bei Langstreckigen, Knöchernen defekten Nach resektion maligner Knochentumoren. Orthopädie (Stuttgart). 2023;52:729–37. 10.1007/s00132-023-04421-2. PubMed
Gilg MM, Gaston CL, Jeys L, Abudu A, Tillman RM, Stevenson JD, et al. The use of a non-invasive extendable prosthesis at the time of revision arthroplasty. Bone Joint J. 2018;100–B(3):370–7. 10.1302/0301-620X.100B3.BJJ-2017-0651.R1. PubMed
Nystrom LM, Morcuende JA. Expanding endoprosthesis for pediatric musculoskeletal malignancy: current concepts and results. Iowa Orthop J. 2010;30:141–9. PubMed PMC
Henderson ER, O’Connor MI, Ruggieri P, Windhager R, Funovics PT, Gibbons CL, et al. Classification of failure of limb salvage after reconstructive surgery for bone tumours: a modified system including biological and expandable reconstructions. Bone Joint J. 2014;96–B(11):1436–40. 10.1302/0301-620X.96B11.34747. PubMed
Thornley P, Vicente M, MacDonald A, Evaniew N, Ghert M, Velez R. Causes and frequencies of reoperations after endoprosthetic reconstructions for extremity tumor surgery: a systematic review. Clin Orthop Relat Res. 2019;477(4):894–902. 10.1097/CORR.0000000000000630. PubMed PMC
Zan P, Wang H, Cai Z, Shen J, Sun W. Revision surgeries for tumor endoprostheses around the knee joint: a mid-long-term follow-up of 20 cases. World J Surg Oncol. 2022;20(1):76. 10.1186/s12957-022-02542-0. PubMed PMC
Sigmund IK, Gamper J, Weber C, Holinka J, Panotopoulos J, Funovics PT, et al. Efficacy of different revision procedures for infected megaprostheses in musculoskeletal tumour surgery of the lower limb. PLoS ONE. 2018;13(7):e0200304. 10.1371/journal.pone.0200304. PubMed PMC
Levin AS, Arkader A, Morris CD. Reconstruction following tumor resections in skeletally immature patients. J Am Acad Orthop Surg. 2017;25(3):204–13. 10.5435/JAAOS-D-15-00619. PubMed
Wilkins RM, Camozzi AB, Gitelis SB. Reconstruction options for pediatric bone tumors about the knee. J Knee Surg. 2005;18(4):305–9. 10.1055/s-0030-1248197. PubMed
Baumgart R, Hinterwimmer S, Krammer M, Muensterer O, Mutschler W. The bioexpandable prosthesis: a new perspective after resection of malignant bone tumors in children. J Pediatr Hematol Oncol. 2005;27(8):452–5. 10.1097/01.mph.0000178268.07830.d5. PubMed
Sambri A, Paganelli C, Parisi SC, Filippini M, Cevolani L, Stimolo D, et al. Does patellar height influence range of motion and anterior knee pain after distal femur endoprosthesis reconstruction? J Clin Med. 2024;13(14):4194. 10.3390/jcm13144194. PubMed PMC