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Adipose derived stem cells - Sources, differentiation capacity and a new target for reconstructive and regenerative medicine

. 2025 May ; 186 () : 118036. [epub] 20250406

Language English Country France Media print-electronic

Document type Journal Article, Review

Adipose-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) derived from adipose tissue with mesenchymal lineage differentiation potential and remarkable potential in regenerative medicine. ADSCs are easily sourced from adipose tissue, share regenerative characteristics akin to other MSCs. Their convenient adherence to plastic culture flasks, coupled with their capacity for in vitro expansion and multi-lineage differentiation, underscores their promise as a robust tool for tissue repair and enhancement. The accessibility of human adipose tissue and the development of minimally invasive isolation protocols have further propelled the autologous use of ADSCs, fueling excitement in both organ repair and regenerative medicine. Consequently, research in ADSCsis experiencing rapid growth. A detailed overview of the current landscape of ADSCs isolation and differentiation capacity including the latest advancements in ADSCs usage, encompassing ongoing clinical investigations are important considerations to understand their potential to shape the landscape of regenerative medicine.

Atherosclerosis Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Department of General and Dental Radiology Pomeranian Medical University in Szczecin Powstańców Wielkopolskich 72 Szczecin 70 111 Poland

Department of General Pharmacology and Pharmacoeconomics Pomeranian Medical University in Szczecin Żołnierska 48 Szczecin 71 230 Poland; Department of Stem Cells and Regenerative Medicine Institute of Natural Fibres and Medicinal Plants Kolejowa 2 Plewiska 62 064 Poland

Department of Obstetrics and Gynecology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Department of Paediatric Dentistry Poznan University of Medical Sciences Poznań Poland

Department of Pediatric Orthopedics and Musculosceletal Oncology Pomeranian Medical University

Department of Toxicology Poznan University of Medical Sciences Poznań 61 631 Poland; Department of Basic and Preclinical Sciences Institute of Veterinary Medicine Nicolaus Copernicus University in Torun Torun 87 100 Poland

Division of Anatomy Department of Human Morphology and Embryology Faculty of Medicine Wroclaw Medical University Wroclaw 50 368 Poland

Division of Anatomy Department of Human Morphology and Embryology Faculty of Medicine Wroclaw Medical University Wroclaw 50 368 Poland; Center of Assisted Reproduction Department of Obstetrics and Gynecology University Hospital and Masaryk University Brno 625 00 Czech Republic; Department of Veterinary Surgery Institute of Veterinary Medicine Nicolaus Copernicus University in Torun Torun 87 100 Poland; North Carolina State University College of Agriculture and Life Sciences Raleigh NC 27695 USA

Division of Anatomy Department of Human Morphology and Embryology Faculty of Medicine Wroclaw Medical University Wroclaw 50 368 Poland; Department of Toxicology Poznan University of Medical Sciences Poznań 61 631 Poland

Division of Histology and Embryology Department of Human Morphology and Embryology Wroclaw Medical University Wroclaw 50 368 Poland

Faculty of Medicine Wroclaw University of Science and Technology Wroclaw Poland; Department of Dermato Venereology 4th Military Hospital Wroclaw Poland

Fertility Infertility and Perinatology Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Graduate Physiology Program North Carolina State University Raleigh NC 27695 USA

University Center for General and Oncological Dermatology Wroclaw Medical University Wroclaw 50 367 Poland

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