Acute Appendicitis in Pregnancy: A Single-Center Retrospective Cohort Study
Status Publisher Language English Country Switzerland Media print-electronic
Document type Journal Article
PubMed
40438728
PubMed Central
PMC12113414
DOI
10.1159/000545862
PII: 545862
Knihovny.cz E-resources
- Keywords
- Abdominal surgery, Acute appendicitis, Appendectomy, Pregnancy, Visceral surgery,
- Publication type
- Journal Article MeSH
INTRODUCTION: During pregnancy, acute appendicitis is responsible for about two-thirds of nontraumatic surgical emergencies. The aim of this study was to investigate whether the group of pregnant patients differs from the group of the normal population in perioperative features and whether surgery during pregnancy affects its further course. METHODS: We retrospectively analyzed a cohort of 1,054 patients who underwent surgery for signs of acute appendicitis. The cohort included 16 pregnant patients (1.5%), 6 patients (37.5%) in the first trimester, 10 patients (62.5%) in the second. Perioperative features of the groups were compared, and postoperative course of pregnancy was followed. RESULTS: We discovered that pregnant patients had a higher ratio of negative appendectomies (25% vs. 5.3%, p = 0.010) and shorter operating time (40 min vs. 51 min, p = 0.013). CONCLUSION: Based on our data, acute appendectomy in pregnancy is associated with a higher rate of negative appendectomy and shorter operating time. Due to the small number of pregnant patients in the group and the occurrence of only one first trimester miscarriage of unknown etiology, it is not possible to clearly draw conclusion about the impact of acute appendectomy on the further course of pregnancy and further investigation is needed.
See more in PubMed
Di Saverio S, Podda M, De Simone B, Ceresoli M, Augustin G, Gori A, et al. . Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020;15(1):27. PubMed PMC
Choi YS, Seo JH, Yi JW, Choe YM, Heo YS, Choi SK. Clinical characteristics of acute appendicitis in pregnancy: 10-year experience at a single institution in South Korea. J Clin Med. 2023;12(9):3277. PubMed PMC
Yu CH, Weng SF, Ho CH, Chen YC, Chen JY, Chang YJ, et al. . Pregnancy outcomes following nonobstetric surgery during gestation: a nationwide population-based case-control study in Taiwan. BMC Pregnancy Childbirth. 2018;18(1):460. PubMed PMC
R Core Team . R: a language and environment for statistical computing; 2024. Available from: https://www.R-project.org/
Posit Team . RStudio: integrated development environment for R; 2024. Available from: http://www.posit.co/
Jaschinski T, Mosch CG, Eikermann M, Neugebauer EA, Sauerland S. Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev. 2018;11(11):CD001546. PubMed PMC
Yu MC, Feng YJ, Wang W, Fan W, Cheng HT, Xu J. Is laparoscopic appendectomy feasible for complicated appendicitis? A systematic review and meta-analysis. Int J Surg. 2017;40:187–97. PubMed
Walker HG, Al Samaraee A, Mills SJ, Kalbassi MR. Laparoscopic appendicectomy in pregnancy: a systematic review of the published evidence. Int J Surg. 2014;12(11):1235–41. PubMed
Adamina M, Andreou A, Arezzo A, Christogiannis C, Di Lorenzo N, Gioumidou M, et al. . EAES rapid guideline: systematic review, meta-analysis, GRADE assessment, and evidence-informed European recommendations on appendicitis in pregnancy. Surg Endosc. 2022;36(12):8699–712. PubMed
Pantelis AG, Machairiotis N, Stavros S, Potiris A, Karampitsakos T, Lapatsanis DP, et al. . Laparoscopic surgery during pregnancy: a meta-review and quality analysis using the assessment of multiple systematic reviews (amstar) 2 instrument. Cureus. 2024;16(6):e63521. PubMed PMC
Zeng Q, Aierken A, Gu SS, Yao G, Apaer S, Anweier N, et al. . Laparoscopic versus open appendectomy for appendicitis in pregnancy: systematic review and meta-analysis. Surg Laparosc Endosc Percutan Tech. 2021;31(5):637–44. PubMed
Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A, et al. . Progestogens for preventing miscarriage: a network meta-analysis. Cochrane Database Syst Rev. 2021;4(4):CD013792. PubMed PMC
Roman A, Ramirez A, Fox NS. Prevention of preterm birth in twin pregnancies. Am J Obstet Gynecol MFM. 2022;4(2S):100551. PubMed
Katkhouda N, Mason RJ, Towfigh S, Gevorgyan A, Essani R. Laparoscopic versus open appendectomy: a prospective randomized double-blind study. Ann Surg. 2005;242(3):439–50. PubMed PMC
Ito K, Ito H, Whang EE, Tavakkolizadeh A. Appendectomy in pregnancy: evaluation of the risks of a negative appendectomy. Am J Surg. 2012;203(2):145–50. PubMed
Pastore PA, Loomis DM, Sauret J. Appendicitis in pregnancy. J Am Board Fam Med. 2006;19(6):621–6. PubMed
Abbasi N, Patenaude V, Abenhaim HA. Management and outcomes of acute appendicitis in pregnancy-population-based study of over 7000 cases. BJOG. 2014;121(12):1509–14. PubMed
Young BC, Hamar BD, Levine D, Roqué H. Medical management of ruptured appendicitis in pregnancy. Obstet Gynecol. 2009;114(2 Pt 2):453–6. PubMed
Zheng X, He X. Development of a nomogram for the prediction of complicated appendicitis during pregnancy. BMC Surg. 2023;23(1):188. PubMed PMC
Lindqvist PG, Pettersson H, Dahlberg M, Sandblom G, Boström L. Appendectomy during pregnancy: rates, safety, and outcomes over a five-year period. A hospital-based follow-up study. J Matern Fetal Neonatal Med. 2023;36(1):2160629. PubMed
Won RP, Friedlander S, Lee SL. Management and outcomes of appendectomy during pregnancy. Am Surg. 2017;83(10):1103–7. PubMed