Camellia sinensis powder rich in epicatechin and polyphenols attenuates isoprenaline induced cardiac injury by activating the Nrf2 HO1 antioxidant pathway in rats
Jazyk angličtina Země Velká Británie, Anglie Médium electronic
Typ dokumentu časopisecké články
PubMed
40596364
PubMed Central
PMC12214831
DOI
10.1038/s41598-025-08720-w
PII: 10.1038/s41598-025-08720-w
Knihovny.cz E-zdroje
- Klíčová slova
- Camellia sinensis, Fibrosis, Inflammation, Isoprenaline, Myocardial infarction,
- MeSH
- antioxidancia * metabolismus farmakologie MeSH
- čajovník čínský * chemie MeSH
- faktor 2 související s NF-E2 * metabolismus MeSH
- hemová oxygenasa (decyklizující) MeSH
- infarkt myokardu * chemicky indukované farmakoterapie metabolismus patologie MeSH
- isoprenalin škodlivé účinky MeSH
- katechin * farmakologie MeSH
- krysa rodu Rattus MeSH
- myokard patologie metabolismus MeSH
- oxidační stres účinky léků MeSH
- polyfenoly * farmakologie chemie MeSH
- poranění srdce * chemicky indukované farmakoterapie metabolismus MeSH
- potkani Long-Evans MeSH
- prášky, zásypy, pudry MeSH
- rostlinné extrakty farmakologie MeSH
- signální transdukce účinky léků MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antioxidancia * MeSH
- faktor 2 související s NF-E2 * MeSH
- hemová oxygenasa (decyklizující) MeSH
- Hmox1 protein, rat MeSH Prohlížeč
- isoprenalin MeSH
- katechin * MeSH
- Nfe2l2 protein, rat MeSH Prohlížeč
- polyfenoly * MeSH
- prášky, zásypy, pudry MeSH
- rostlinné extrakty MeSH
Myocardial infarction is a leading cause of death and morbidity in individuals with cardiovascular diseases. Natural antioxidants, such as those found in green tea leaves, are beneficial in preventing these diseases. This study evaluated the protective effects of green tea leaves powder against isoprenaline (ISO)-induced myocardial infarction in rats. Four groups of male Long Evans rats were used: Control, Control + green tea leaves powder, ISO, and ISO + green tea leaves powder. Organ and blood plasma samples were collected to measure oxidative stress biomarkers, biochemical parameters, and gene expressions. Furthermore, tissue sections were prepared and stained histologically. ISO-induced rats showed decreased cellular antioxidants (catalase activity and glutathione concentration) and elevated oxidative stress markers. Notable inflammatory cell infiltration and fibrosis were observed in the heart and kidneys of ISO-induced rats. Supplementation with green tea leaves powder significantly restored catalase activity and glutathione concentration (p < 0.05) in plasma and tissues. It also considerably reduced lipid peroxidation, nitric oxide, and advanced oxidation protein products (p < 0.05) in ISO-administered rats. Furthermore, green tea leaves powder supplementation halted inflammatory gene expression (p < 0.05), restored antioxidant genes (p < 0.05) such as Nrf-2-HO-1, and prevented cardiac fibrosis in ISO-administered rats. Green tea leaves powder supplementation may reduce oxidative stress, inflammation, and fibrosis in ISO-administered rats, potentially through the Nrf-2-HO-1-mediated restoration of antioxidant enzymes and prevention of heart inflammation.
BCSIR Laboratories Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh
Department of Pharmaceutical Sciences North South University Dhaka Bangladesh
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