Pluronics, also known as poloxamers, are amphiphilic triblock copolymers widely employed in drug delivery systems due to their tunable self-assembly and biocompatibility. Among them, Pluronic F68 (Poloxamer 188) exhibits thermoresponsive behavior in aqueous solution, forming ordered supramolecular structures at high concentrations and temperatures. In this work, we investigate the morphological and rheological properties of a 45 wt% Pluronic F68 aqueous system at different temperatures through a combination of experimental and computational approaches. Rheological measurements and Small-Angle X-ray Scattering (SAXS) confirm the formation of a body-centered cubic (BCC) structure at higher temperatures and highlight the emergence of viscoelastic solid-like behavior. To support and extend these findings, Dissipative Particle Dynamics (DPD) simulations are employed to model the nanostructure evolution and the impact of temperature on self-assembly and material properties. This integrated approach provides a consistent framework to characterize the temperature-induced transition from fluid-like to solid-like states and sets the groundwork for future simulation studies incorporating drug cargo. The results offer valuable insights into the design of thermoresponsive drug delivery systems and demonstrate the potential of DPD in capturing complex structure-property relationships in amphiphilic polymer systems.

Department of Molecular and Mesoscopic Modelling The Czech Academy of Sciences Institute of Chemical Process Fundamentals Rozvojová Prague 135 1 Czech Republic

DICMaPI Università degli Studi di Napoli Federico 2 P le Tecchio 80 Napoli 80125 Italy

DICMaPI Università degli Studi di Napoli Federico 2 P le Tecchio 80 Napoli 80125 Italy; Department of Engineering Università degli Studi del Sannio Corso Garibaldi 107 Benevento 82100 Italy

DISAT Institute of Chemical Engineering Politecnico di Torino C so Duca degli Abruzzi 24 Torino 10129 Italy

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