Open science is now established as an important paradigm for publicly funded research. The main principle being that to ensure best use of research data and integrity of the scientific process the information from experiments should be made widely and freely available. However, dedicated technical infrastructure to enable useful access to comprehensive experimental information in molecular biophysics is lacking, in particular in regard to repositories for raw measurement data. The Molecular Biophysics Database (MBDB) was created to fill this gap. The MBDB provides a common and extensible framework to store and access raw measurement data from a growing number of biophysical methods, currently including bio-layer interferometry, isothermal titration calorimetry, surface plasmon resonance, and microscale thermophoresis, with additional methods planned for the future. Alongside the raw measurement data from these methods, a rich set of metadata to enable data reuse is captured in accordance with the FAIR data management principles. An overview of the data models and technologies that were used to create the MBDB is presented here.

AFFINImeter Software 4 Science Developments Edificio Emprendia Campus Vida 15782 Santiago de Compostela Spain

Czech Education and Scientific NETwork Generála Píky 430 26 160 00 Prague 6 Czech Republic

Institute of Biotechnology of the Czech Academy of Sciences Průmyslová 595 252 50 Vestec Czech Republic

Institute of Structural and Molecular Biology School of Natural Sciences Birkbeck University of London Malet Street London WC1E 7HX UK

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