Příprava eLearningového kurzu je v závislosti na zvolených technických prostředcích několikanásobně pracnější v porovnání s prezenční výukou. Aby se příprava eLearningu vyplatila, měl být kurz použitelný opakovaně. V oborech, kde dochází k rychlému vývoji, je třeba kurzy aktualizovat a tyto úpravy znovu zvyšují celkové náklady. Je tedy žádoucí kurz nebo jeho části použít ve více kontextech paralelně a použít takový systém, ve kterém změny nepředstavují vysoké náklady. Východiskem je strukturovat látku do malých samostatných monotematických výukových jednotek, které pak lze použít znovu i v jiném kontextu. Takovým jednotkám se říká „znovupoužitelné výukové objekty“ (Reusable Learning Objects – RLO). Tyto výukové objekty je třeba přehledně ukládat a sdílet v digitálním repozitáři. Aplikací pro ukládání digitálních objektů je celá řada, přesto se zdá, že by mohlo být výhodné použít pro tento účel otevřený a samoorganizující se systém, jakým je technologie Wiki.
In dependence upon selected technical means, creation of e-learning courses is more complex and laborious than preparation for traditional (attendance) education. Thus, re-use of single courses is highly desirable. However, it is quite often necessary to update the, especially in rapidly deloping fields; such changes represent additional costs. Hence it is highly advantageous to re-use the courses or their parts in more contexts, while using a system where changes do not bring about high costs. A possible solution is to structuralize broad themes into small standalone monothematic educational parts which can be used again in other contexts. Such parts are called Reusable Learning Objects (RLO). The objects should be well arranged and shared in a digital repository. Even though there is a wide selection of digital objects repositories, it might seem more advantageous to use a self-organizing and naturally growing system such as Wiki technology.
- Keywords
- znovupoužitelné výukové objekty, digitální úložiště, Wiki,
- MeSH
- Audiovisual Aids utilization MeSH
- Libraries, Digital utilization MeSH
- Internet utilization MeSH
- Medical Informatics * methods MeSH
- Computer-Assisted Instruction methods trends MeSH
- Education, Medical * methods trends MeSH
- Information Storage and Retrieval * methods utilization MeSH
Mass spectrometry raw data repositories, including Metabolomics Workbench and MetaboLights, have contributed to increased transparency in metabolomics studies and the discovery of novel insights in biology by reanalysis with updated computational metabolomics tools. Herein, we reanalyzed the previously published lipidomics data from nine algal species, resulting in the annotation of 1437 lipids achieving a 40% increase in annotation compared to the previous results. Specifically, diacylglyceryl-carboxyhydroxy-methylcholine (DGCC) in Pavlova lutheri and Pleurochrysis carterae, glucuronosyldiacylglycerol (GlcADG) in Euglena gracilis, and P. carterae, phosphatidylmethanol (PMeOH) in E. gracilis, and several oxidized phospholipids (oxidized phosphatidylcholine, OxPC; phosphatidylethanolamine, OxPE; phosphatidylglycerol, OxPG; phosphatidylinositol, OxPI) in Chlorella variabilis were newly characterized with the enriched lipid spectral databases. Moreover, we integrated the data from untargeted and targeted analyses from data independent tandem mass spectrometry (DIA-MS/MS) acquisition, specifically the sequential window acquisition of all theoretical fragment-ion MS/MS (SWATH-MS/MS) spectra, to increase the lipidomic annotation coverage. After the creation of a global library of precursor and diagnostic ions of lipids by the MS-DIAL untargeted analysis, the co-eluted DIA-MS/MS spectra were resolved in MRMPROBS targeted analysis by tracing the specific product ions involved in acyl chain compositions. Our results indicated that the metabolite quantifications based on DIA-MS/MS chromatograms were somewhat inferior to the MS1-centric quantifications, while the annotation coverage outperformed those of the untargeted analysis of the data dependent and DIA-MS/MS data. Consequently, integrated analyses of untargeted and targeted approaches are necessary to extract the maximum amount of metabolome information, and our results showcase the value of data repositories for the discovery of novel insights in lipid biology.
- Publication type
- Journal Article MeSH
Purpose: Thermal dose-effect relations have demonstrated that clinical effectiveness of hyperthermia would benefit from more controlled heating of the tumor. Hyperthermia treatment planning (HTP) is a potent tool to study strategies enabling target conformal heating, but its accuracy is affected by patient modeling approximations. Homogeneous phantoms models are being used that do not match the body shape of patients in treatment position and often have unrealistic target volumes. As a consequence, simulation accuracy is affected, and performance comparisons are difficult. The aim of this study is to provide the first step toward standardization of HTP simulation studies in terms of patient modeling by introducing the Erasmus Virtual Patient Repository (EVPR): a virtual patient model database.Methods: Four patients with a tumor in the head and neck or the pelvis region were selected, and corresponding models were created using a clinical segmentation procedure. Using the Erasmus University Medical Center standard procedure, HTP was applied to these models and compared to HTP for commonly used surrogate models.Results: Although this study was aimed at presenting the EVPR database, our study illustrates that there is a non-negligible difference in the predicted SAR patterns between patient models and homogeneous phantom-based surrogate models. We further demonstrate the difference between actual and simplified target volumes being used today.Conclusion: Our study describes the EVPR for the research community as a first step toward standardization of hyperthermia simulation studies.
- MeSH
- Head MeSH
- Hyperthermia * MeSH
- Hyperthermia, Induced * MeSH
- Humans MeSH
- Computer Simulation MeSH
- Reference Standards MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The pervasive use of electronic records in healthcare increases the dependency on technology due to the lack of a physical support for the records. Downtime in the EHR system is unavoidable, due to software, infrastructure, energy failures or even natural disasters, so there is a need to develop a contingency plan ensuring patient care continuity and minimizing risks on health care delivery. To mitigate these risks, an application was developed allowing healthcare delivery providers to retrieve medication prescriptions for inpatient or emergency care patients using the CDA R2 document repository as information source. In this paper we describe the strategy and the implementation results.
- MeSH
- Nuclear Reactors history utilization MeSH
- Power Plants instrumentation statistics & numerical data utilization MeSH
- Nuclear Energy legislation & jurisprudence MeSH
- Humans MeSH
- Environmental Monitoring economics methods standards MeSH
- Hazardous Waste economics prevention & control legislation & jurisprudence MeSH
- Sewage legislation & jurisprudence MeSH
- Radioactive Waste economics adverse effects MeSH
- Government Programs MeSH
- Check Tag
- Humans MeSH
- Geographicals
- Slovakia MeSH
Centrální úložiště elektronických receptů bylo zřízeno dle zákona o léčivech, jako organizační součást Státního ústavu pro kontrolu léčiv. Komunikace přes centrální úložiště povede ke vzniku systému elektronických lékových záznamů občanů a významně zefektivní a omezí rizika v komunikaci mezi lékaři, lékárnami a pacienty. Zároveň umožní výdej léčivých přípravků v nové kategorii výdeje bez lékařského předpisu s omezením.
The central repository of electronic prescriptions was established in confirmity to the Act on Pharmaceuticals as an organisational part of the State Institute for Drug Control. Communication via the central repository will lead to the creation of citizens' electronic drug records and will significantly limit risks of communication among doctors, pharmacies and patients. It will also make possible to launch a new category of medicinal products – medicinal products dispensed over-the-counter with restriction.
- MeSH
- Databases as Topic utilization MeSH
- Electronic Prescribing MeSH
- Forms and Records Control methods utilization MeSH
- Internet trends utilization MeSH
- Drug and Narcotic Control methods legislation & jurisprudence MeSH
- Pharmaceutical Preparations economics MeSH
- Pharmacies economics organization & administration trends MeSH
- Electronics, Medical methods trends legislation & jurisprudence MeSH
- Drug Prescriptions economics standards MeSH
- Humans MeSH
- Legislation, Drug utilization MeSH
- Check Tag
- Humans MeSH
BACKGROUND: One of the main challenges in modern science is the amount of data produced by the experimental work; it is difficult to store, organize and share the scientific data and to extract the wealth of knowledge. Experimental method descriptions in scientific publications are often incomplete, which complicates experimental reproducibility. The proposed system was created in order to address these issues. It provides a solution for management of the experimental data and metadata to support the reproducibility. IMPLEMENTATION: The system is implemented as a repository for experiment descriptions and experimental data. It has three main entry points: desktop application for protocol design and data processing, web interface dedicated for protocol and data management, and web-based interface for mobile devices suitable for the field experiments. The functionality of desktop client can be extended using the custom plug-ins for data extraction and data processing. The system provides several methods to support experimental reproducibility: standardized terminology support, data and metadata at a single location, standardized protocol design or protocol evolution. RESULTS AND DISCUSSION: The system was tested in the framework of international infrastructure project AQUAEXCEL with five pilot installations at different institutes. The general testing in Tissue culture certified laboratory, Institute of complex systems and IFREMER verified the usability under different research infrastructures. The specific testing focused on the data processing modules and plug-ins demonstrated the modularity of the system for the specific conditions. The BioWes system represents experimental data as black box and therefore can handle any data type so as to provide broad usability for a variety of experiments and provide the data management infrastructure to improve the reproducibility and data sharing. CONCLUSIONS: The proposed system provides the tools for standard data management operations and extends the support by the standardization possibilities, protocol evolution with visualization features and modularity based on the data processing modules and device communication plug-ins. The software can be used at different organization levels: from a single researcher (to improve data organization) to research consortium through the central protocols management repository. Support from the protocol design until being shared with the standardization features helps to improve the reproducibility of research work. The platform provides support from experimental protocol design to cooperation using simple sharing.
Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It is therefore time for international collaboration in DIPG research, to provide new hope for children, parents and medical professionals fighting DIPG. In a first step towards collaboration, in 2011, a network of biologists and clinicians working in the field of DIPG was established within the European Society for Paediatric Oncology (SIOPE) Brain Tumour Group: the SIOPE DIPG Network. By bringing together biomedical professionals and parents as patient representatives, several collaborative DIPG-related projects have been realized. With help from experts in the fields of information technology, and legal advisors, an international, web-based comprehensive database was developed, The SIOPE DIPG Registry and Imaging Repository, to centrally collect data of DIPG patients. As for April 2016, clinical data as well as MR-scans of 694 patients have been entered into the SIOPE DIPG Registry/Imaging Repository. The median progression free survival is 6.0 months (95% Confidence Interval (CI) 5.6-6.4 months) and the median overall survival is 11.0 months (95% CI 10.5-11.5 months). At two and five years post-diagnosis, 10 and 2% of patients are alive, respectively. The establishment of the SIOPE DIPG Network and SIOPE DIPG Registry means a paradigm shift towards collaborative research into DIPG. This is seen as an essential first step towards understanding the disease, improving care and (ultimately) cure for children with DIPG.
- MeSH
- Child MeSH
- Glioma diagnostic imaging MeSH
- Information Services * MeSH
- Humans MeSH
- Magnetic Resonance Imaging * MeSH
- International Cooperation * MeSH
- Young Adult MeSH
- Brain Stem Neoplasms diagnostic imaging MeSH
- Image Processing, Computer-Assisted MeSH
- Pons diagnostic imaging MeSH
- Child, Preschool MeSH
- Registries * MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Europe MeSH
