Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha [PPARGC1A]
- Terms
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peroxisome proliferator-activated receptor-gamma coactivator 1 alpha
PPAR gama koaktivátor-1-alfa
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PGC-1-alpha Protein
PPARGC-1-alpha Protein
PPARGC1a Protein
A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.
- DUI
- D000071248 MeSH Browser
- CUI
- M000613853
- Previous indexing
- Transcription Factors (2004-2016)
- History note
- 2017
- Public note
- 2017
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 5
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 7
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
PPARGC1A protein, human Chemical MeSH Browser
Ppargc1a protein, mouse Chemical MeSH Browser
Ppargc1a protein, rat Chemical MeSH Browser
ppargc1a protein, zebrafish Chemical MeSH Browser