Src Homology 2 Domain-Containing, Transforming Protein 1 [transformující protein 1 obsahující src homologní doménu 2]
- Terms
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SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
SHC-Transforming Protein 1
SHC1 (Src Homology 2 Domain-Containing) Protein
SHC1 Protein
ShcA Protein
Src Homology 2 Domain-Containing-Transforming Protein C1
An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
- DUI
- D000071425 MeSH Browser
- CUI
- M0454582
- History note
- 2017; use SHC SIGNALING ADAPTOR PROTEINS 2009-2016
- Public note
- 2017; see SHC SIGNALING ADAPTOR PROTEINS 2009-2016
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
SHC1 protein, human Chemical MeSH Browser
Shc1 protein, mouse Chemical MeSH Browser
Shc1 protein, rat Chemical MeSH Browser