Src Homology 2 Domain-Containing, Transforming Protein 1 [transformující protein 1 obsahující src homologní doménu 2]

topical
1
Terms

SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
SHC-Transforming Protein 1
SHC1 (Src Homology 2 Domain-Containing) Protein
SHC1 Protein
ShcA Protein
Src Homology 2 Domain-Containing-Transforming Protein C1

Persistent link   https://www.medvik.cz/link/D000071425
Definition

An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.

DUI
D000071425 MeSH Browser
CUI
M0454582
History note
2017; use SHC SIGNALING ADAPTOR PROTEINS 2009-2016
Public note
2017; see SHC SIGNALING ADAPTOR PROTEINS 2009-2016

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AG
agonists 0
AN
analysis 0
AI
antagonists & inhibitors 0
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 0
DE
drug effects 0
EC
economics 0
GE
genetics 0
HI
history 0
IM
immunology 0
IP
isolation & purification 0
ME
metabolism 1
PK
pharmacokinetics 0
PD
pharmacology 0
PH
physiology 0
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D12 Amino Acids, Peptides, and Proteins 16
D12.644 Peptides 1 380
D12.644.360 Intracellular Signaling Peptides and Proteins 174
D12.644.360.024 Adaptor Proteins, Signal Transducing 176
D12.644.360.024.330 Shc Signaling Adaptor Proteins
D12.644.360.024.330.500 Src Homology 2 Domain-Containing, Transforming Protein 1 1
D12.644.360.024.330.750 Src Homology 2 Domain-Containing, Transforming Protein 2
D12.644.360.024.330.875 Src Homology 2 Domain-Containing, Transforming Protein 3
D12.776 Proteins 2 575
D12.776.157 Carrier Proteins 546
D12.776.157.057 Adaptor Proteins, Signal Transducing 176
D12.776.157.057.162 Shc Signaling Adaptor Proteins
D12.776.157.057.162.500 Src Homology 2 Domain-Containing, Transforming Protein 1 1
D12.776.157.057.162.750 Src Homology 2 Domain-Containing, Transforming Protein 2
D12.776.157.057.162.875 Src Homology 2 Domain-Containing, Transforming Protein 3
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.024 Adaptor Proteins, Signal Transducing 176
D12.776.476.024.424 Shc Signaling Adaptor Proteins
D12.776.476.024.424.500 Src Homology 2 Domain-Containing, Transforming Protein 1 1
D12.776.476.024.424.750 Src Homology 2 Domain-Containing, Transforming Protein 2
D12.776.476.024.424.875 Src Homology 2 Domain-Containing, Transforming Protein 3

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